ArticleThe Journal of physiology2001
Rectification of cGMP-activated channels induced by phosphorylation in dogfish retinal 'on' bipolar cells.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Activation mechanism of a neuromodulator-gated pacemaker ionic current.Journal of neurophysiology · 2017Article
- Regulation of ON bipolar cell activity.Progress in retinal and eye research · 2008Review
- Efficiency of synaptic transmission of single-photon events from rod photoreceptor to rod bipolar dendrite.Biophysical journal · 2006Article
- Modulation by brain natriuretic peptide of GABA receptors on rat retinal ON-type bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Desensitization of the mGluR6 transduction current in tiger salamander On bipolar cells.The Journal of physiology · 2004Article
- Metabotropic glutamate receptors in vertebrate retina.Documenta ophthalmologica. Advances in ophthalmology · 2003Review
- Potentiation of 'on' bipolar cell flash responses by dim background light and cGMP in dogfish retinal slices.The Journal of physiology · 2002Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Whole-cell current responses to brief flashes were obtained from voltage-clamped 'on' bipolar cells in dark-adapted dogfish retinal slices. When internal Ca2+ was buffered to low levels, the current-voltage (I-V) relation of their flash responses was linear, with a reversal potential near 0 mV. 2. On elevating internal Ca2+ the light-dependent I-V relation showed outward rectification, such that the current response to a flash decreased e-fold for a hyperpolarization of 22 mV. 3. Inclusion of a CaMKII inhibitory peptide in the patch-pipette solution removed the rectification even in the presence of 50 microM Ca2+. 4. These results are consistent with CaMKII phosphorylation of cGMP-activated channels leading to a voltage-dependent reduction in conductance (outward rectification) and a reduced light response. The voltage-dependent property suggests that phosphorylation creates an energy barrier near the outer part of the channel, reducing the flow principally of monovalent cations. 5. This is the first reported instance of CaMKII phosphorylation acting to change the electrical characteristics of a membrane channel from linear to rectifying. 6. Ca2+-dependent desensitization by background light and channel rectification may underlie the change in centre-surround organization of the visual system with light adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.