ArticleThe Journal of physiology2001
Simultaneous recording of receptor current and intraciliary Ca2+ concentration in salamander olfactory receptor cells.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Sensory Transduction in Photoreceptors and Olfactory Sensory Neurons: Common Features and Distinct Characteristics.Frontiers in cellular neuroscience · 2021Review
- Transduction and Adaptation Mechanisms in the Cilium or Microvilli of Photoreceptors and Olfactory Receptors From Insects to Humans.Frontiers in cellular neuroscience · 2021Review
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- Odor tracking in aquatic organisms: the importance of temporal and spatial intermittency of the turbulent plume.Scientific reports · 2020Article
- Second messenger molecules have a limited spread in olfactory cilia.The Journal of general physiology · 2018Article
- Smelling Time: A Neural Basis for Olfactory Scene Analysis.Trends in neurosciences · 2016Review
- Odorant-induced responses recorded from olfactory receptor neurons using the suction pipette technique.Journal of visualized experiments : JoVE · 2012Article
- The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response.Nature neuroscience · 2011Article
- Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia.The Journal of general physiology · 2010Article
- The effect of external sodium concentration on sodium-calcium exchange in frog olfactory receptor cells.The Journal of physiology · 2007Article
- Calmodulin contributes to gating control in olfactory calcium-activated chloride channels.The Journal of general physiology · 2006Article
- Model of calcium oscillations due to negative feedback in olfactory cilia.Biophysical journal · 2006Article
- Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The Ca-activated Cl channel and its control in rat olfactory receptor neurons.The Journal of general physiology · 2003Article
- Odorant receptor expression defines functional units in the mouse olfactory system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The suction pipette technique was combined with laser spot fluorescence microscopy to record simultaneously odour-induced current responses and intraciliary Ca2+ concentration from isolated salamander olfactory receptor cells loaded with the fluorescent Ca2+ indicator fluo-3. 2. When exposed for 1 s to increasing odour concentrations both the suction pipette current and fluo-3 fluorescence increased dynamically, rising with a similar time course. Thereafter, the fluorescence signal decayed more slowly, outlasting the current response by 0.56 +/- 0.12 s. 3. The fluo-3 fluorescence evoked by progressively increasing odour concentrations varied in an approximately linear manner with the magnitude of the suction pipette current. 4. Prolonged odour stimulation evoked synchronous oscillations in both suction pipette current and intraciliary calcium concentration with a mean period of 4.5 +/- 0.3 s. 5. When external Na+ was omitted from the stimulating solution the oscillation period for both the current and fluorescence signals was lengthened by a factor of 1.9 +/- 0.2 in comparison with the oscillation period when stimulated in Ringer solution. 6. These results support the currently accepted mechanism for Ca2+ homeostasis within the olfactory cilia, and are consistent with the notion that the oscillations induced by prolonged odour exposure represent the coupled oscillation of Ca2+ and cyclic nucleotide concentrations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.