ArticleGut2001
MIP-2 secreted by epithelial cells increases neutrophil and lymphocyte recruitment in the mouse intestine.
Article in Gut, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 152 citations in OpenAlex.
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- Multiomic Integration Reveals Taxonomic Shifts Correlate to Serum Cytokines in an Antibiotics Model of Gut Microbiome Disruption.Cellular and molecular bioengineering · 2025Article
- Mucosal Immunity: Lessons from the Lower Respiratory and Small Intestinal Epithelia.Biomedicines · 2025Review
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- Polymeric DNase-I nanozymes targeting neutrophil extracellular traps for the treatment of bowel inflammation.Nano convergence · 2024Article
- The Antioxidant Properties ofAntioxidants (Basel, Switzerland) · 2023Article
- Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis.Gut microbes · 2023Article
- A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.Science translational medicine · 2023Article
- Neutrophils recruited to immunization sites initiating vaccine-induced antibody responses by locally expressing BAFF.iScience · 2022Article
- Systems biology approach highlights mechanistic differences between Crohn's disease and ulcerative colitis.Scientific reports · 2021Article
- Identification of TLR2 Signalling Mechanisms Which Contribute to Barrett's and Oesophageal Adenocarcinoma Disease Progression.Cancers · 2021Article
- Nerolidol Mitigates Colonic Inflammation: An Experimental Study Using both In Vivo and In Vitro Models.Nutrients · 2020Article
- Expression of Proteinase-Activated Receptor 2 During Colon Volvulus in the Horse.Frontiers in veterinary science · 2020Article
- Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace.Scientific reports · 2019Article
- A New Understanding of the Role of IL-1 in Age-Related Intervertebral Disc Degeneration in a Murine Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway.EBioMedicine · 2019Article
- Therapeutic effects of a single injection of human umbilical mesenchymal stem cells on acute and chronic colitis in mice.Scientific reports · 2019Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundInvasion of the intestinal mucosa by leucocytes is a characteristic of intestinal inflammation but the role of the epithelium in orchestrating this recruitment has not been examined in vivo. Cultured intestinal epithelial cells secrete a wide variety of chemokines, often in response to agents present in the intestinal lumen. Macrophage inflammatory protein 2 (MIP-2) is a chemokine that attracts neutrophils, and its secretion from intestinal epithelial cells is enhanced by inflammatory stimuli such as interleukin 1beta. We hypothesised that the production of MIP-2 by epithelial cells would increase leucocyte migration into the intestine.
aimTo study the effects of a chemokine secreted from intestinal epithelial cells in vivo.
methodsMIP-2 was expressed in the mouse intestinal epithelium using an epithelial cell specific promoter from the gene encoding the intestinal fatty acid binding protein. The intestines of these transgenic mice were then analysed.
resultsEpithelial cells from transgenic mice expressed MIP-2 but wild-type mice did not. Neutrophil recruitment, examined by myeloperoxidase (MPO) staining and total MPO activity per unit weight of intestine, was significantly increased in transgenic mice in both the small intestine and proximal colon, and this was blocked by anti-MIP-2 antibody treatment. Both intraepithelial and lamina propria lymphocytes were also increased in transgenic mice. They showed chemotactic activity to MIP-2 in the Boyden chambers and expressed MIP-2 receptor (CXCR-2) mRNA confirmed by reverse transcription-polymerase chain reaction.
conclusionThese experiments are the first to show a functional role for epithelial chemokines in vivo and reveal an unexpected role for the neutrophil chemokine MIP-2 in controlling mucosal lymphocyte migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.