ArticleNucleic acids research2001
The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Effect of TAR hairpin stabilization on HIV-1 reverse transcription.Journal of virology · 2026Article
- A binary trait model reveals the fitness effects of HIV-1 escape from T cell responses.bioRxiv : the preprint server for biology · 2024Article
- Elevated HIV Viral Load is Associated with Higher Recombination Rate In Vivo.Molecular biology and evolution · 2024Article
- RNA recombination: non-negligible factor for preventing emergence or reemergence of Senecavirus A.Frontiers in veterinary science · 2024Article
- Elevated HIV viral load is associated with higher recombination ratebioRxiv : the preprint server for biology · 2023Article
- Retroviral nucleocapsid proteins and DNA strand transfers.Biochimie open · 2018Review
- Template-primer binding affinity and RNase H cleavage specificity contribute to the strand transfer efficiency of HIV-1 reverse transcriptase.The Journal of biological chemistry · 2018Article
- Review
- Tet-On Systems For Doxycycline-inducible Gene Expression.Current gene therapy · 2016Review
- U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence.Biochemistry · 2014Article
- Fifteen to twenty percent of HIV substitution mutations are associated with recombination.Journal of virology · 2014Article
- Identifying recombination hot spots in the HIV-1 genome.Journal of virology · 2014Article
- Structural determinants of TAR RNA-DNA annealing in the absence and presence of HIV-1 nucleocapsid protein.Nucleic acids research · 2011Article
- HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation.The Journal of biological chemistry · 2011Article
- Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC.Nucleic acids research · 2011Article
- Accurately measuring recombination between closely related HIV-1 genomes.PLoS computational biology · 2010Article
- Characterization and frequency of a newly identified HIV-1 BF1 intersubtype circulating recombinant form in São Paulo, Brazil.Virology journal · 2010Article
- Longitudinal quasispecies analysis of viral variants in HIV type 1 dually infected individuals highlights the importance of sequence identity in viral recombination.AIDS research and human retroviruses · 2010Article
- Single-molecule study of DNA polymerization activity of HIV-1 reverse transcriptase on DNA templates.Journal of molecular biology · 2010Article
- A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.The Journal of biological chemistry · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Template switching during reverse transcription is crucial for retroviral replication. While strand transfer on the terminal repeated sequence R is essential to achieve reverse transcription, template switching from internal regions of the genome (copy choice) leads to genetic recombination. We have developed an experimental system to study copy-choice recombination in vitro along the HIV-1 genome. We identify here several genomic regions, including the R sequence, where copy choice occurred at high rates. The frequency of copy choice occurring in a given region of template was strongly influenced by the surrounding sequences, an observation that suggests a pivotal role of the folding of template RNA in the process. The sequence R, instead, constituted an exception to this rule since it was a strong hot-spot for copy choice in the different sequence contexts tested. We suggest therefore that the structure of this region has been optimised during viral evolution to ensure efficient template switching independently from the sequences that might surround it.
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