Trial reportAnnals of the rheumatic diseases2001
Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: a six month double blind, randomised, placebo controlled study.
Trial report in Annals of the rheumatic diseases, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03665116 (Effects of Arginine on Osteoarthritis), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Arginine on Osteoarthritis: A Pilot Clinical Trial
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.The Cochrane database of systematic reviews · 2012Pooled it
- Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence.Arthritis research & therapy · 2006Pooled it
- Trial
- Comparative effectiveness of B and e vitamins with diclofenac in reducing pain due to osteoarthritis of the knee.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2015Trial
- Anti-inflammatory response of dietary vitamin E and its effects on pain and joint structures during early stages of surgically induced osteoarthritis in dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2013Trial
- Assessment of vitamin E status among patients with newly diagnosed primary knee osteoarthritis in Cameroon.Scientific reports · 2026Article
- No genetic causal association between circulating alpha-tocopherol levels and osteoarthritis, a two-sample Mendelian randomization analysis.Scientific reports · 2024Article
- Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 Regulators That Affect Expression and Enzymatic Activity.International journal of molecular sciences · 2023Review
- Article
- Genetic liability for diet-derived circulating antioxidants, oxidative stress, and risk of osteoarthritis: a Mendelian randomization study.Frontiers in nutrition · 2023Article
- Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix DegradationOxidative medicine and cellular longevity · 2021Article
- The Role of Vitamin E in Preventing and Treating Osteoarthritis - A Review of the Current Evidence.Frontiers in pharmacology · 2018Review
- Associations between dietary antioxidants intake and radiographic knee osteoarthritis.Clinical rheumatology · 2016Article
- High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis.Osteoarthritis and cartilage · 2014Article
- Drug repositioning: playing dirty to kill pain.CNS drugs · 2014Review
- Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis.International journal of molecular sciences · 2013Review
- Two faces of vitamin E in the lung.American journal of respiratory and critical care medicine · 2013Review
- Isoforms of Vitamin E Differentially Regulate PKCJournal of clinical & cellular immunology · 2013Article
- Can levels of antioxidants in synovial fluid predict the severity of primary knee osteoarthritis: a preliminary study.SpringerPlus · 2013Article
- Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population.Therapeutic advances in musculoskeletal disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere is a putative role for antioxidant treatment in osteoarthritis (OA) based on animal, epidemiological, and human clinical studies. Vitamin E, a fat soluble vitamin, is one of the major dietary antioxidants. Short term clinical studies using vitamin E in the form of alpha-tocopherol suggested a benefit over placebo of similar dimension to that of diclofenac for relief of OA pain.
methodsA six month, double blind, randomised, placebo controlled study of vitamin E 500 IU/day was carried out. Primary outcome measures were pain, stiffness, and function. Statistical analysis was performed on an intention to treat basis.
results77 patients were included in the study. Vitamin E showed no benefit over placebo at one month, three months, or six months for any of the outcome measures. The placebo group had higher pain levels (p=0.15) and body mass index (p=0.03) at baseline, and lower pain levels (p=0.02) at completion of the study. Radiological score, exercise score, age, or antioxidant intake at baseline or six months did not differ between the groups. The reasons for the better performance of the placebo group are uncertain but may relate to the initially higher pain score and subsequent regression to the mean.
conclusionsVitamin E shows no benefit for the management of symptomatic knee OA. The role of vitamin E in preventing OA progression is currently under investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.