Evidence map›Paper›PMID 11557487›Full record

ArticleAntimicrobial agents and chemotherapy2001

Antimalarial drugs clear resistant parasites from partially immune hosts.

P Cravo, R Culleton, P Hunt, D Walliker, M J Mackinnon

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Adaptive evolution and fixation of drug-resistant Plasmodium falciparum genotypes in pregnancy-associated malaria: 9-year results from the QuEERPAM study.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012
    Article
  9. Article
  10. Article
  11. The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
  12. Article
  13. Article
  14. Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model.Proceedings of the National Academy of Sciences of the United States of America · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

P CravoInstitute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Rd., Edinburgh EH9 3JT, United Kingdom.
R Culleton
P Hunt
D Walliker
M J Mackinnon

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circumstantial evidence in human malaria suggests that elimination of parasites by drug treatment meets higher success rates in individuals having some background immunity. In this study, using the rodent malaria model Plasmodium chabaudi, we show that drug-resistant parasites can be cleared by drugs when the host is partially immune.

Indexed as

Plasmodium chabaudiAnimalsAntimalarialsChloroquineDisease Models, AnimalDrug ResistanceImmunizationMalariaMefloquineMiceAntimalarialsChloroquineMefloquine

Identifiers

PMID11557487
PMCPMC90749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.