ArticleJournal of anatomy2001
Role of uppermost superficial surface layer of articular cartilage in the lubrication mechanism of joints.
Article in Journal of anatomy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 148 citations in OpenAlex.
- Mechanical Wear of Degraded Articular Cartilage.Annals of biomedical engineering · 2025Article
- Cartilage-bioinspired tenacious concrete-like hydrogel verified via in-situ testing.Nature communications · 2025Article
- How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis? A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2024Review
- Brushing Up on Cartilage Lubrication: Polyelectrolyte-Enhanced Tribological Rehydration.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- [Effects of removing superficial layer of cartilage on the surface morphology and mechanical behavior of cartilage].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Creating an Optimal In Vivo Environment to Enhance Outcomes Using Cell Therapy to Repair/Regenerate Injured Tissues of the Musculoskeletal System.Biomedicines · 2022Review
- Biotribological Tests of Osteochondral Grafts after Treatment with Pro-Inflammatory Cytokines.Cartilage · 2021Article
- Articular and Artificial Cartilage, Characteristics, Properties and Testing Approaches-A Review.Polymers · 2021Review
- Bioprinting: From Tissue and Organ Development toChemical reviews · 2020Review
- Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage.Scientific reports · 2016Article
- The distribution of superficial zone protein (SZP)/lubricin/PRG4 and boundary mode frictional properties of the bovine diarthrodial joint.Journal of biomechanics · 2015Article
- Biodynamic performance of hyaluronic acid versus synovial fluid of the knee in osteoarthritis.Methods (San Diego, Calif.) · 2015Article
- Boundary cartilage lubrication: review of current concepts.Wiener medizinische Wochenschrift (1946) · 2014Review
- A study of the diffusion characteristics of normal, delipidized and relipidized articular cartilage using magnetic resonance imaging.Journal of materials science. Materials in medicine · 2013Article
- Relationship between wettability and lubrication characteristics of the surfaces of contacting phospholipid-based membranes.Cell biochemistry and biophysics · 2013Article
- Pendulum mass affects the measurement of articular friction coefficient.Journal of biomechanics · 2013Article
- Cationic agent contrast-enhanced computed tomography imaging of cartilage correlates with the compressive modulus and coefficient of friction.Osteoarthritis and cartilage · 2013Article
- Targeted In Situ Biosynthetic Transcriptional Activation in Native Surface-Level Human Articular Chondrocytes during Lesion Stabilization.Cartilage · 2012Article
- Solid-state NMR spectroscopy provides atomic-level insights into the dehydration of cartilage.The journal of physical chemistry. B · 2011Article
- Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis.Molecular biology reports · 2011Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The uppermost superficial surface layer of articular cartilage, the 'lamina splendens' which provides a very low friction lubrication surface in articular joints, was investigated using atomic force microscopy (AFM). Complementary specimens were also observed under SEM at -10 degrees C without dehydration or sputter ion coating. Fresh adult pig osteochondral specimens were prepared from the patellas of pig knee joints and digested with the enzymes, hyaluronidase, chondroitinase ABC and alkaline protease. Friction coefficients between a pyrex glass plate and the osteochondral specimens digested by enzymes as well as natural (undigested) specimens were measured, using a thrust collar apparatus. Normal saline, hyaluronic acid (HA) and a mixture of albumin, globulin, HA (AGH) were used as lubrication media. The surface irregularities usually observed in SEM studies were not apparent under AFM. The articular cartilage surface was resistant to hyaluronidase and also to chondroitinase ABC, but a fibrous structure was exhibited in alkaline protease enzymes-digested specimens. AFM analysis revealed that the thickness of the uppermost superficial surface layer of articular cartilage was between 800 nm and 2 microm in adult pig articular cartilage. The coefficient of friction (c.f.) was significantly higher in chondroitinase ABC and alkaline protease enzymes digested specimens. Generally, in normal saline lubrication medium, c.f. was higher in comparison to HA and AGH lubrication media. The role of the uppermost, superficial surface layer of articular cartilage in the lubrication mechanism of joints is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.