Trial reportEuropean journal of drug metabolism and pharmacokinetics
Determination of pharmacokinetic parameters of stavudine in Japanese patients infected with HIV-1, using a Gaussian-like input rate function.
Trial report in European journal of drug metabolism and pharmacokinetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Orange juice and its component, hesperidin, decrease the expression of multidrug resistance-associated protein 2 in rat small intestine and liver.Journal of biomedicine & biotechnology · 2011Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We sought to examine variation in pharmacokinetic parameters of stavudine in Japanese patients infected with HIV-1. Stavudine concentrations were measured in two hemophiliacs (HIV-1 asymptomatic carriers (ACs)) and two non-hemophiliacs (both ACs). To simulate the plasma stavudine concentrations following a single oral dose, we used a Gaussian-like input rate function in a single compartment model. The theoretical equation successfully simulated changes in the time course of plasma stavudine concentrations in all four patients. The mean+/-SD of Tmax, Cmax, AUC0-infinity, and t 1/2 were 0.96+/-0.26 hr, 478+/-90 ng/mL, 1112+/-136 ng x hr/mL, and 1.26+/-0.23 hr, respectively. Pharmacokinetic characteristics were comparable to those reported in the literature, although the mean of Cmax was slightly lower and means of Tmax and t 1/2 slightly longer than those previously reported. Interpatient variability in plasma stavudine concentrations was not as dramatic as that seen with lamivudine. Thus, we confirmed the validity of the uniform therapeutic regimen of stavudine in Japanese people with HIV-1 infection.
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