ArticleProceedings of the National Academy of Sciences of the United States of America2001
CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 105 citations in OpenAlex.
- Renaming the 'OS-D/CSP' Family (Part 2): '4-Cysteine Soluble Proteins' (4CSPs)-Intracellular Functions.Insects · 2026Review
- Identification of shared mechanisms between Alzheimer's disease and atherosclerosis by integrated bioinformatics analysis.European journal of medical research · 2025Article
- Identification of ARMH4 and WIPF3 as human podocyte proteins with potential roles in immunomodulation and cytoskeletal dynamics.PloS one · 2023Article
- Changes in the proteome of sea urchin Paracentrotus lividus coelomocytes in response to LPS injection into the body cavity.PloS one · 2020Article
- Expression of PRR11 protein and its correlation with pancreatic cancer and effect on survival.Oncology letters · 2017Article
- Association of non-synonymous variants inJournal of geriatric cardiology : JGC · 2016Article
- WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion.Scientific reports · 2016Article
- The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP).Cellular microbiology · 2012Article
- WIP remodeling actin behind the scenes: how WIP reshapes immune and other functions.International journal of molecular sciences · 2012Review
- Bifunctional role of the Treponema pallidum extracellular matrix binding adhesin Tp0751.Infection and immunity · 2011Article
- WASP and WAVE family proteins: friends or foes in cancer invasion?Cancer science · 2010Review
- Self-assembly of filopodia-like structures on supported lipid bilayers.Science (New York, N.Y.) · 2010Article
- WASP family proteins: their evolution and its physiological implications.Molecular biology of the cell · 2010Article
- Diversity of polyproline recognition by EVH1 domains.Frontiers in bioscience (Landmark edition) · 2009Review
- Recent advances in the biology of WASP and WIP.Immunologic research · 2009Review
- The WASP and WAVE family proteins.Genome biology · 2009Review
- EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane curvature-dependent actin polymerization.The EMBO journal · 2008Article
- Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly.PLoS pathogens · 2008Article
- Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway.BMC cell biology · 2008Article
- Src phosphorylation of cortactin enhances actin assembly.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Neuronal Wiskott-Aldrich syndrome protein (N-WASP) has emerged as a central regulator of the actin cytoskeleton with abilities to integrate multiple upstream signal inputs and transmit them to the Arp2/3 complex. Here, we demonstrate that native N-WASP is present in a tight complex with a proline-rich protein, CR16, which shares approximately 25% identity with WASP interacting protein. CR16 is encoded by a gene previously cloned as a glucocorticoid-regulated mRNA from a rat hippocampal cDNA library. Although N-WASP is expressed ubiquitously, full-length CR16 protein is found predominately in the brain. CR16 and N-WASP colocalize in primary hippocampal neurons and at the tips of their growth cone filopodia. In vitro, CR16 directly binds both monomeric and filamentous actin but does not affect the kinetics of actin polymerization mediated by N-WASP and the Arp2/3 complex. Sequence homologues of CR16 are found not only in other vertebrates but also in the invertebrate Caenorhabditis elegans and in yeast. Thus, CR16 and WASP interacting protein belong to a family of N-WASP-binding proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.