ArticleProceedings of the National Academy of Sciences of the United States of America2001
Erratic overdispersion of three molecular clocks: GPDH, SOD, and XDH.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Origin of ethnic groups, linguistic families, and civilizations in China viewed from the Y chromosome.Molecular genetics and genomics : MGG · 2021Review
- Molecular analysis and bioinformatic characterization of cooper, zinc-superoxide dismutase (Cu/Zn-sod) gene of Caiman latirostris.Molecular biology reports · 2020Article
- Genome-Wide Identification and Characterization ofMarine drugs · 2019Article
- Universal pacemaker of genome evolution in animals and fungi and variation of evolutionary rates in diverse organisms.Genome biology and evolution · 2014Article
- Universal pacemaker of genome evolution.PLoS computational biology · 2012Article
- Superoxide dismutases: a physiopharmacological update.Journal of physiology and biochemistry · 2009Review
- Fundamental concepts in genetics: genetics and the understanding of selection.Nature reviews. Genetics · 2009Review
- Genome-wide acceleration of protein evolution in flies (Diptera).BMC evolutionary biology · 2006Article
- TreeFam: a curated database of phylogenetic trees of animal gene families.Nucleic acids research · 2006Article
- Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- A new Drosophila spliceosomal intron position is common in plants.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- A methodological bias toward overestimation of molecular evolutionary time scales.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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Authors and funding
3 authors.
Funding
Abstract
The neutrality theory predicts that the rate of neutral molecular evolution is constant over time, and thus that there is a molecular clock for timing evolutionary events. It has been observed that the variance of the rate of evolution is generally larger than expected according to the neutrality theory, which has raised the question of how reliable the molecular clock is or, indeed, whether there is a molecular clock at all. We have carried out an extensive investigation of three proteins, glycerol-3-phosphate dehydrogenase (GPDH), superoxide dismutase (SOD), and xanthine dehydrogenase (XDH). We have observed that (i) the three proteins evolve erratically through time and across lineages and (ii) the erratic patterns of acceleration and deceleration differ from locus to locus, so that one locus may evolve faster in one than another lineage, whereas the opposite may be the case for another locus. The observations are inconsistent with the predictions made by various subsidiary hypotheses proposed to account for the overdispersion of the molecular clock.
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