ArticleProceedings of the National Academy of Sciences of the United States of America2001
Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed, 176 citations in OpenAlex.
- Review
- Regulatory mechanisms controlling store-operated calcium entry.Frontiers in physiology · 2023Review
- How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP.Cell communication and signaling : CCS · 2022Article
- Lipin-1-derived diacylglycerol activates intracellular TRPC3 which is critical for inflammatory signaling.Cellular and molecular life sciences : CMLS · 2021Article
- TRPC channels: Structure, function, regulation and recent advances in small molecular probes.Pharmacology & therapeutics · 2020Review
- TRPCs: Influential Mediators in Skeletal Muscle.Cells · 2020Review
- Calcium Channels in Adult Brain Neural Stem Cells and in Glioblastoma Stem Cells.Frontiers in cellular neuroscience · 2020Review
- Beyond the CRAC: Diversification of ion signaling in B cells.Immunological reviews · 2019Review
- Review
- Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes.Frontiers in physiology · 2018Article
- Permeation, regulation and control of expression of TRP channels by trace metal ions.Pflugers Archiv : European journal of physiology · 2015Review
- Tweeters, Woofers and Horns: The Complex Orchestration of Calcium Currents in T Lymphocytes.Frontiers in immunology · 2015Review
- Regulation of store-operated calcium entry by FK506-binding immunophilins.Cell calcium · 2013Article
- Weft, warp, and weave: the intricate tapestry of calcium channels regulating T lymphocyte function.Frontiers in immunology · 2013Article
- Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways.PloS one · 2013Article
- On the role of endothelial TRPC3 channels in endothelial dysfunction and cardiovascular disease.Cardiovascular & hematological agents in medicinal chemistry · 2012Review
- Redox regulation of endothelial canonical transient receptor potential channels.Antioxidants & redox signaling · 2011Review
- The physiological function of store-operated calcium entry.Neurochemical research · 2011Review
- Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions.PLoS biology · 2011Article
- Contribution of TRPC1 and Orai1 to Ca(2+) entry activated by store depletion.Advances in experimental medicine and biology · 2011Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian Trp proteins are candidates for plasma membrane calcium channels regulated by receptor activation or by intracellular calcium store depletion [capacitative calcium entry (CCE)]. One extensively investigated member of the Trp family, the human Trp3 (hTrp3), behaves as a receptor-activated, calcium-permeable, nonselective cation channel when expressed in cell lines and does not appear to be activated by store depletion. Nonetheless, there is good evidence that Trp3 can be regulated by interacting with inositol trisphosphate receptors (IP(3)Rs), reminiscent of the conformational coupling mode of CCE. To investigate the role of Trp3 in CCE, and its regulation by IP(3)R, we transiently expressed hTrp3 in the wild-type DT40 chicken B lymphocyte cell line and its variant lacking IP(3)R. Expression of hTrp3 in either wild-type or IP(3)R-knockout cells did not increase basal membrane permeability, but resulted in a substantially greater divalent cation entry after thapsigargin-induced store depletion. This hTrp3-dependent divalent cation entry was significantly greater in the wild type than in IP(3)R-knockout cells. Thus, it appears that in this cell line, hTrp3 forms channels that are store-operated by both IP(3)R-dependent and IP(3)R-independent mechanisms. Trp3, or one of its structural relatives, is a candidate for the store-operated, nonselective cation channels observed in smooth muscle cells and other cell types.
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