ArticleProceedings of the National Academy of Sciences of the United States of America2001
Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 115 citations in OpenAlex.
- Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.JCI insight · 2018Trial
- Histones-mediated lymphocyte apoptosis during sepsis is dependent on p38 phosphorylation and mitochondrial permeability transition.PloS one · 2013Trial
- The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome.Frontiers in immunology · 2023Review
- Recent advances in neutrophil chemotaxis abnormalities during sepsis.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2022Review
- miR-21 Regulates Immune Balance Mediated by Th17/Treg in Peripheral Blood of Septic Rats during the Early Phase through Apoptosis Pathway.Biochemistry research international · 2022Article
- Priming with FLO8-deficient Candida albicans induces Th1-biased protective immunity against lethal polymicrobial sepsis.Cellular & molecular immunology · 2021Article
- Role of the adaptive immune response in sepsis.Intensive care medicine experimental · 2020Review
- Stromal Cell-Derived Factor-1 Enhances the Therapeutic Effects of Human Endometrial Regenerative Cells in a Mouse Sepsis Model.Stem cells international · 2020Article
- The volatile anesthetic sevoflurane reduces neutrophil apoptosisFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis.Cell death & disease · 2019Review
- miR‑148 family members are putative biomarkers for sepsis.Molecular medicine reports · 2019Article
- Bioinformatics analysis to screen for critical genes between survived and non‑survived patients with sepsis.Molecular medicine reports · 2018Article
- Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.Current opinion in hematology · 2018Review
- Neutrophil dysregulation during sepsis: an overview and update.Journal of cellular and molecular medicine · 2017Review
- Hydroxysafflor Yellow A Attenuates the Apoptosis of Peripheral Blood CD4Frontiers in pharmacology · 2017Article
- Grape seed proanthocyanidin extract protects lymphocytes against histone-induced apoptosis.PeerJ · 2017Article
- Alterations of Thymic Epithelial Cells in Lipopolysaccharide-induced Neonatal Thymus Involution.Chinese medical journal · 2016Article
- Persistent lymphopenia after diagnosis of sepsis predicts mortality.Shock (Augusta, Ga.) · 2014Article
- Role of circulating lymphocytes in patients with sepsis.BioMed research international · 2014Review
- Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.Nature reviews. Immunology · 2013Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Sepsis remains a significant clinical conundrum, and recent clinical trials with anticytokine therapies have produced disappointing results. Animal studies have suggested that increased lymphocyte apoptosis may contribute to sepsis-induced mortality. We report here that inhibition of thymocyte apoptosis by targeted adenovirus-induced thymic expression of human IL-10 reduced blood bacteremia and prevented mortality in sepsis. In contrast, systemic administration of an adenovirus expressing IL-10 was without any protective effect. Improvements in survival were associated with increases in Bcl-2 expression and reductions in caspase-3 activity and thymocyte apoptosis. These studies demonstrate that thymic apoptosis plays a critical role in the pathogenesis of sepsis and identifies a gene therapy approach for its therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.