ArticleMolecular biology of the cell2001
The domain structure of centromeres is conserved from fission yeast to humans.
Article in Molecular biology of the cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 86 citations in OpenAlex.
- Comparative Genomic Analysis Reveals Key Changes in the Genome ofInternational journal of molecular sciences · 2024Article
- How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance.Cells · 2020Review
- Nuclear Mechanics in the Fission Yeast.Cells · 2019Review
- Article
- Article
- A diffusion model for the coordination of DNA replication in Schizosaccharomyces pombe.Scientific reports · 2016Article
- Article
- Chromosome domain architecture and dynamic organization of the fission yeast genome.FEBS letters · 2015Review
- Article
- Epigenetic Regulation of Chromatin States in Schizosaccharomyces pombe.Cold Spring Harbor perspectives in biology · 2015Review
- Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.Cell cycle (Georgetown, Tex.) · 2015Article
- csi2p modulates microtubule dynamics and organizes the bipolar spindle for chromosome segregation.Molecular biology of the cell · 2014Article
- Lessons learned from counting molecules: how to lure CENP-A into the kinetochore.Open biology · 2014Article
- Chromosome conformation maps in fission yeast reveal cell cycle dependent sub nuclear structure.Nucleic acids research · 2014Article
- Centromeric barrier disruption leads to mitotic defects in Schizosaccharomyces pombe.G3 (Bethesda, Md.) · 2014Article
- Centromeric motion facilitates the mobility of interphase genomic regions in fission yeast.Journal of cell science · 2013Article
- Review
- Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast.Open biology · 2012Article
- Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.The Journal of cell biology · 2011Article
- The essentiality of the fungus-specific Dam1 complex is correlated with a one-kinetochore-one-microtubule interaction present throughout the cell cycle, independent of the nature of a centromere.Eukaryotic cell · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
The centromeric DNA of fission yeast is arranged with a central core flanked by repeated sequences. The centromere-associated proteins, Mis6p and Cnp1p (SpCENP-A), associate exclusively with central core DNA, whereas the Swi6 protein binds the surrounding repeats. Here, electron microscopy and immunofluorescence light microscopy reveal that the central core and flanking regions occupy distinct positions within a heterochromatic domain. An "anchor" structure containing the Ndc80 protein resides between this heterochromatic domain and the spindle pole body. The organization of centromere-associated proteins in fission yeast is reminiscent of the multilayered structures of human kinetochores, indicating that such domain structure is conserved in eukaryotes.
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