ArticleInfection and immunity2001
DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
27 citing papers in PubMed, 93 citations in OpenAlex.
- Insights into Divergent Leishmaniasis Pathogenesis: A Quantitative Flagellar Proteomic Comparison ofMicroorganisms · 2026Article
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- CD8Frontiers in cellular and infection microbiology · 2021Article
- T Cell Specificity: A Great Challenge in Chagas Disease.Frontiers in immunology · 2021Review
- An Animal Model of Acute and Chronic Chagas Disease With the Reticulotropic Y Strain ofFrontiers in immunology · 2019Article
- Article
- Impact of benznidazole treatment on the functional response of Trypanosoma cruzi antigen-specific CD4+CD8+ T cells in chronic Chagas disease patients.PLoS neglected tropical diseases · 2018Article
- SjHSP70, a recombinant Schistosoma japonicum heat shock protein 70, is immunostimulatory and induces protective immunity against cercarial challenge in mice.Parasitology research · 2015Article
- CD8(+) T cell-mediated immunity during Trypanosoma cruzi infection: a path for vaccine development?Mediators of inflammation · 2014Review
- Article
- Investigating the Chaperone Properties of a Novel Heat Shock Protein, Hsp70.c, from Trypanosoma brucei.Journal of parasitology research · 2014Article
- TcVac3 induced control of Trypanosoma cruzi infection and chronic myocarditis in mice.PloS one · 2013Article
- Recombinant yellow fever viruses elicit CD8+ T cell responses and protective immunity against Trypanosoma cruzi.PloS one · 2013Article
- A DNA vaccine encoding for TcSSP4 induces protection against acute and chronic infection in experimental Chagas disease.International journal of biological sciences · 2011Article
- Prophylactic efficacy of TcVac2 against Trypanosoma cruzi in mice.PLoS neglected tropical diseases · 2010Article
- Mucosal adjuvanticity of a Shigella invasin complex with dna-based vaccines.Clinical and vaccine immunology : CVI · 2009Article
- Novel protective antigens expressed by Trypanosoma cruzi amastigotes provide immunity to mice highly susceptible to Chagas' disease.Clinical and vaccine immunology : CVI · 2008Article
- Previously unrecognized vaccine candidates control Trypanosoma cruzi infection and immunopathology in mice.Clinical and vaccine immunology : CVI · 2008Article
- Vaccination with Trypanosoma rangeli reduces the infectiousness of dogs experimentally infected with Trypanosoma cruzi.Vaccine · 2007Article
- Molecular cloning and characterization of a cytosolic heat shock protein 70 from Naegleria fowleri.Parasitology research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Murine immunization with Trypanosoma cruzi KMP11-HSP70 fused genes but not the KMP11 gene alone elicited both an immunoglobulin G2a long-lasting humoral immune response against KMP11 protein and activation of CD8+ cytotoxic T lymphocytes specific for two KMP11 peptides containing A2 motifs. Moreover, protection against the parasite challenge was observed after immunization with the chimeric gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.