ArticleInfection and immunity2001
Transient transgenic expression of gamma interferon promotes Legionella pneumophila clearance in immunocompetent hosts.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Mucosal-associated invariant T cells and Vδ2Clinical and experimental immunology · 2020Trial
- Molecular evolution and adaptations ofFrontiers in cellular and infection microbiology · 2026Review
- Review
- Viewing Legionella pneumophila Pathogenesis through an Immunological Lens.Journal of molecular biology · 2019Review
- Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against MurineInfection and immunity · 2019Article
- Potential Role of Gr-1+ CD8+ T Lymphocytes as a Source of Interferon-γ and M1/M2 Polarization during the Acute Phase of Murine Legionella pneumophila Pneumonia.Journal of innate immunity · 2018Article
- IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense.Mucosal immunology · 2016Article
- The transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages.PloS one · 2014Article
- Persistence of the bacterial pathogen Granulibacter bethesdensis in chronic granulomatous disease monocytes and macrophages lacking a functional NADPH oxidase.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- T cell-mediated host immune defenses in the lung.Annual review of immunology · 2013Review
- Roles of interleukin-17 in an experimental Legionella pneumophila pneumonia model.Infection and immunity · 2012Article
- Legionella pneumophila type II secretion dampens the cytokine response of infected macrophages and epithelia.Infection and immunity · 2011Article
- Molecular pathogenesis of infections caused by Legionella pneumophila.Clinical microbiology reviews · 2010Review
- Interferons direct an effective innate response to Legionella pneumophila infection.The Journal of biological chemistry · 2009Article
- Purification of Legiobactin and importance of this siderophore in lung infection by Legionella pneumophila.Infection and immunity · 2009Article
- c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection.Vaccine · 2008Article
- In vivo effect of adhesion inhibitor heparin on Legionella pneumophila pathogenesis in a murine pneumonia model.Intensive care medicine · 2008Article
- Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila.Infection and immunity · 2008Article
- Cyclic di-GMP stimulates protective innate immunity in bacterial pneumonia.Infection and immunity · 2007Article
- Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide.Alcohol (Fayetteville, N.Y.) · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Gamma interferon (IFN-gamma) and T1-phenotype immune responses are important components of host defense against a variety of intracellular pathogens, including Legionella pneumophila. The benefit of intrapulmonary adenovirus-mediated IFN-gamma gene therapy was investigated in a nonlethal murine model of experimental L. pneumophila pneumonia. Intratracheal (i.t.) administration of 10(6) CFU of L. pneumophila induced the expression of T1 phenotype cytokines, such as IFN-gamma and interleukin-12 (IL-12). Natural killer cells were identified as the major cellular source of IFN-gamma. To determine if enhanced expression of IFN-gamma in the lung could promote pulmonary clearance of L. pneumophila, we i.t. administered 5 x 10(8) PFU of a recombinant adenovirus vector containing the murine IFN-gamma cDNA (AdmIFN-gamma) concomitant with L. pneumophila. We observed a 10-fold decrease in lung bacterial CFU at day 2 in the AdmIFN-gamma-treated group compared to controls (P < 0.01). Alveolar macrophages isolated from AdmIFN-gamma-treated animals displayed enhanced killing of intracellular L. pneumophila organisms ex vivo. Similar improvements in bacterial clearance were observed with i.t. recombinant IFN-gamma treatment. The transient transgenic expression of IL-12, a known inducer of IFN-gamma and promoter of T1-type immune responses, resulted in more modest improvement in bacterial clearance (sixfold reduction; P < 0.05). These results demonstrate that, even in immunocompetent hosts, exogenous administration or transient transgenic expression of IFN-gamma, and to a lesser extent IL-12, may be of potential therapeutic benefit in the treatment of patients with Legionella pneumonia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.