ArticleInfection and immunity2001
Locus of enterocyte effacement from Citrobacter rodentium: sequence analysis and evidence for horizontal transfer among attaching and effacing pathogens.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 219 citations in OpenAlex.
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- Pathogenesis and therapeutic strategies in the interaction between gut microbiota and enterohemorrhagic Escherichia coli infection.FEMS microbiology reviews · 2026Review
- Developing a simple, cost-effective proof-of-concept vaccine candidate against EHEC for cattle.PloS one · 2026Article
- The small regulatory RNA DsrA silences the locus of enterocyte effacement of enteropathogenicmicroPublication biology · 2025Article
- Further Evaluation of EnterohemorrhagicVaccines · 2024Article
- PurA is the main target of aurodox, a type III secretion system inhibitor.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Efficacy of EHEC gold nanoparticle vaccines evaluated with the Shiga toxin-producingMicrobiology spectrum · 2024Article
- Quorum sensing modulates bacterial virulence and colonization dynamics of the gastrointestinal pathogenGut microbes · 2023Article
- Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen.Science advances · 2023Article
- QseC sensor kinase modulates the human microbiota during enterohemorrhagic Escherichia coli O157:H7 infection in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen.bioRxiv : the preprint server for biology · 2023Article
- Protective Role of the Toll-Like Receptor 5 Agonist KMRC011 against Murine Colitis Induced byJournal of microbiology and biotechnology · 2023Article
- IRE1α-Driven Inflammation Promotes Clearance of Citrobacter rodentium Infection.Infection and immunity · 2022Article
- The role of Dock2 on macrophage migration and functions during Citrobacter rodentium infection.Clinical and experimental immunology · 2021Article
- Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components.Biomolecules · 2021Review
- Reversal of Pathogen-Induced Barrier Defects in Intestinal Epithelial Cells by Contra-pathogenicity Agents.Digestive diseases and sciences · 2021Article
- Fluorescence Detection of Type III Secretion Using a Glu-CyFur Reporter System inMicroorganisms · 2020Article
- The Ethanolamine-Sensing Transcription Factor EutR Promotes Virulence and Transmission during Citrobacter rodentium Intestinal Infection.Infection and immunity · 2020Article
- Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity.Microorganisms · 2020Review
56 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The family of attaching and effacing (A/E) bacterial pathogens, which includes diarrheagenic enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC), remains a significant threat to human and animal health. These bacteria intimately attach to host intestinal cells, causing the effacement of brush border microvilli. The genes responsible for this phenotype are encoded in a pathogenicity island called the locus of enterocyte effacement (LEE). Citrobacter rodentium is the only known murine A/E pathogen and serves as a small animal model for EPEC and EHEC infections. Here we report the full DNA sequence of C. rodentium LEE and provide a comparative analysis with the published LEEs from EPEC, EHEC, and the rabbit diarrheagenic E. coli strain RDEC-1. Although C. rodentium LEE shows high similarities throughout the entire sequence and shares all 41 open reading frames with the LEE from EPEC, EHEC, and RDEC-1, it is unique in its location of the rorf1 and rorf2/espG genes and the presence of several insertion sequences (IS) and IS remnants. The LEE of EPEC and EHEC is inserted into the selC tRNA gene. In contrast, the Citrobacter LEE is flanked on one side by an operon encoding an ABC transport system, and an IS element and sequences homologous to Shigella plasmid R100 and EHEC pO157 flank the other. The presence of plasmid sequences next to C. rodentium LEE suggests that the prototype LEE resided on a horizontally transferable plasmid. Additional sequence analysis reveals that the 3-kb plasmid in C. rodentium is nearly identical to p9705 in EHEC O157:H7, suggesting that horizontal plasmid transfer among A/E pathogens has occurred. Our results indicate that the LEE has been acquired by C. rodentium and A/E E. coli strains independently during evolution.
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