ArticleInfection and immunity2001
Increase of gammadelta T lymphocytes in murine lungs occurs during recovery from pulmonary infection by Nocardia asteroides.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- γδ T Cells Mediate Protection against Neutrophil-associated Lung Inflammation in Pulmonary Melioidosis.American journal of respiratory cell and molecular biology · 2024Article
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- γδ T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces.Immunological reviews · 2020Review
- IL-22 is required for the induction of bronchus-associated lymphoid tissue in tolerant lung allografts.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Article
- Article
- IL-17 and γδ T-lymphocytes play a critical role in innate immunity against Nocardia asteroides GUH-2.Microbes and infection · 2012Article
- Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia.BMC immunology · 2012Article
- Regulatory effect of gammadelta T cells on IL-17+ uveitogenic T cells.Investigative ophthalmology & visual science · 2010Article
- Gammadelta T cells and Th17 cytokines in hypersensitivity pneumonitis and lung fibrosis.Translational research : the journal of laboratory and clinical medicine · 2009Article
- Protective role of gammadelta T cells in spontaneous ocular inflammation.Investigative ophthalmology & visual science · 2009Article
- IL-17A-expressing T cells are essential for bacterial clearance in a murine model of hypersensitivity pneumonitis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Hypertonic saline increases gammadeltaT cell-mediated killing of activated neutrophils.Critical care medicine · 2008Article
- Roles of heat shock proteins and gamma delta T cells in inflammation.American journal of respiratory cell and molecular biology · 2008Review
- IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury.Inflammation · 2008Article
- Evidence for the involvement of lung-specific gammadelta T cell subsets in local responses to Streptococcus pneumoniae infection.European journal of immunology · 2007Article
- Pulmonary dendritic cells and alveolar macrophages are regulated by gammadelta T cells during the resolution of S. pneumoniae-induced inflammation.The Journal of pathology · 2007Article
- gammadelta T lymphocytes-selectable cells within the innate system?Journal of clinical immunology · 2007Review
- Response of lung gammadelta T cells to experimental sepsis in mice.Immunology · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have demonstrated that gammadelta T lymphocytes are important for host resistance to pulmonary infection of the murine lung by log-phase cells of Nocardia asteroides. To study the role of gammadelta T cells in nocardial interactions in the murine lung, C57BL/6J wild type and C57BL/6J-Tcrd (gammadelta T-cell knockout mice) were infected intranasally with log-phase cells of N. asteroides GUH-2. At 3, 5, and 7 days after infection, the gammadelta T cells were quantified by multiparameter flow cytometry. At the same time, Gram and hematoxylin-eosin stains of paraffin sections were performed to monitor the host responses. The data showed that gammadelta T lymphocytes increased significantly within the lungs after intranasal infection, and the peak of this cellular increase occurred at 5 days. Furthermore, at this time, greater than 50% of the CD3 T-cell receptor (TCR)-positive (CD3+) cells were gammadelta TCR positive. Histological examination clearly showed divergent inflammatory responses in the lungs of wild-type mice compared to gammadelta T-cell knockout mice. The C57BL/6J-Tcrd mice were less capable of clearing the organism, and the polymorphonuclear leukocyte response lasted longer than in wild-type C57BL/6J mice. These results showed that gammadelta T cells were actively involved in modulating the innate host responses to murine pulmonary infection by N. asteroides.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.