ArticleInfection and immunity2001
Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses.Pharmaceutics · 2024Article
- TetR-like regulator BP1026B_II1561 controls aromatic amino acid biosynthesis and intracellular pathogenesis inFrontiers in microbiology · 2024Article
- A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model.Journal of translational medicine · 2020Article
- An evolving perspective about the origins of childhood undernutrition and nutritional interventions that includes the gut microbiome.Annals of the New York Academy of Sciences · 2014Review
- Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.PloS one · 2014Article
- Feast or famine: the host-pathogen battle over amino acids.Cellular microbiology · 2013Review
- Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands.Journal of medicinal chemistry · 2013Article
- Dipterinyl calcium pentahydrate inhibits intracellular mycobacterial growth in human monocytes via the C-C chemokine MIP-1β and nitric oxide.Infection and immunity · 2013Article
- Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis.Clinical and vaccine immunology : CVI · 2012Article
- Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.PloS one · 2012Article
- Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.PLoS neglected tropical diseases · 2012Article
- Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections.Infection and immunity · 2011Article
- Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts.Experimental & molecular medicine · 2011Article
- Synthesis and characterization of PEGylated toll like receptor 7 ligands.Bioconjugate chemistry · 2011Article
- Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs.Infection and immunity · 2010Article
- Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Cytokines involved in interferon-gamma production by human macrophages.Journal of innate immunity · 2010Article
- Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy.Immunotherapy · 2009Review
- Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates.Bioconjugate chemistry · 2009Article
- Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Bacterial DNA and its synthetic immunostimulatory oligodeoxynucleotide analogs (ISS-ODN) activate innate immunity and promote Th1 and cytotoxic T-lymphocyte immune responses. Based on these activities, we investigated whether ISS-ODN could modify the course of Mycobacterium avium infection. M. avium growth in vitro was significantly inhibited by ISS-ODN treatment of human and mouse macrophages, and M. avium growth in vivo was similarly inhibited in C57BL/6 mice treated with ISS-ODN. This protective effect of ISS-ODN was largely independent of tumor necrosis factor alpha (TNF-alpha), interleukin 12 (IL-12), nitric oxide, NADPH oxidase, alpha/beta interferon (IFN-alpha/beta), and IFN-gamma. In contrast, we found that the induction of indoleamine 2,3-dioxygenase (IDO) was required for the antimycobacterial effect of ISS-ODN. To evaluate the potential for synergism between ISS-ODN and other antimycobacterial agents, treatment with a combination of ISS-ODN and clarithromycin (CLA) was tested in vitro and in vivo. ISS-ODN significantly enhanced the therapeutic effect of CLA in both human and mouse macrophages and in C57BL/6 mice. This study newly identifies IDO as being involved in the antimicrobial activity of ISS-ODN and suggests the usefulness of ISS-ODN when used in combination with conventional chemotherapy for microbial infections.
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