ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Leukemia inhibitory factor determines the growth status of injured adult sensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
79 citing papers in PubMed, 207 citations in OpenAlex.
- Expression of Cytokines, Chmokines and Growth Factors in Patients Undergoing Cataract Surgery with Femtosecond Laser Pretreatment.PloS one · 2015Trial
- Revisiting the Peripheral Nerve Injury and Regeneration.Neuromolecular medicine · 2026Review
- Glycoprotein 130 improves repressor element‑1 silencing transcription factor‑related axon regenerative capacity in peripheral nerves with aging.Molecular medicine reports · 2025Article
- Genes in Axonal Regeneration.Molecular neurobiology · 2024Review
- Article
- Stepwise combined cell transplantation using mesenchymal stem cells and induced pluripotent stem cell-derived motor neuron progenitor cells in spinal cord injury.Stem cell research & therapy · 2024Article
- Impact of galectin-3 on neurotrophic factor expression by PCR array: potential implications for the human cornea.Frontiers in cell and developmental biology · 2024Article
- An Integrative Approach to the Current Treatment of HIV-Associated Neurocognitive Disorders and the Implementation of Leukemia Inhibitor Factor as a Mediator of Neurocognitive Preservation.Life (Basel, Switzerland) · 2023Review
- Unleashing Intrinsic Growth Pathways in Regenerating Peripheral Neurons.International journal of molecular sciences · 2022Review
- Nanogel-mediated delivery of oncomodulin secreted from regeneration-associated macrophages promotes sensory axon regeneration in the spinal cord.Theranostics · 2022Article
- Neuroimmune interactions and immunoengineering strategies in peripheral nerve repair.Progress in neurobiology · 2022Review
- Melatonin promotes Schwann cell dedifferentiation and proliferation through the Ras/Raf/ERK and MAPK pathways, and glial cell-derived neurotrophic factor expression.Experimental and therapeutic medicine · 2020Article
- Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury.Cellular and molecular life sciences : CMLS · 2020Review
- Injectable, photoresponsive hydrogels for delivering neuroprotective proteins enabled by metal-directed protein assembly.Science advances · 2020Article
- Hypoxia-Preconditioned Placenta-Derived Mesenchymal Stem Cells Rescue Optic Nerve Axons Via Differential Roles of Vascular Endothelial Growth Factor in an Optic Nerve Compression Animal Model.Molecular neurobiology · 2020Article
- Intra-axonal mechanisms driving axon regeneration.Brain research · 2020Review
- Interleukin-6 contributes to initiation of neuronal regeneration program in the remote dorsal root ganglia neurons after sciatic nerve injury.Histochemistry and cell biology · 2019Article
- The Spinal Transcriptome after Cortical Stroke: In Search of Molecular Factors Regulating Spontaneous Recovery in the Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- An In Vitro Model for Conditioning Lesion Effect.Cellular and molecular neurobiology · 2019Article
- The Success and Failure of the Schwann Cell Response to Nerve Injury.Frontiers in cellular neuroscience · 2019Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
Conditioning injury to adult mammalian sensory neurons enhances their regeneration potential. Here we show that leukemia inhibitory factor (LIF) is a fundamental component of the conditioning response. Conditioning injury in vivo significantly increases the intrinsic growth capacity of sensory neurons in vitro from LIF+/+ mice. This conditioning effect is significantly blunted in sensory neurons from LIF-/- mice. Enhanced growth is rescued in vitro in LIF-/- mice by the addition of exogenous LIF, and the effect blocked by human LIF-05, an LIF receptor antagonist. Furthermore, we demonstrate that LIF promotes elongating but not arborizing neurite outgrowth in vitro and is required for normal regeneration of injured adult sensory neurons in vivo. LIF is also functionally protective to peptidergic sensory neurons after nerve damage in vivo. Our results indicate that the alteration in intrinsic growth status of injured sensory neurons depends, at least in part, on LIF.
Indexed as
Identifiers
11549727PMC6762988W1634672871What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.