ReviewJournal of mammary gland biology and neoplasia2001
Cadherin junctions in mammary tumors.
Review in Journal of mammary gland biology and neoplasia, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- Article
- Cadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target.Frontiers in oncology · 2019Review
- Depletion of mitochondrial reactive oxygen species downregulates epithelial-to-mesenchymal transition in cervical cancer cells.Oncotarget · 2017Article
- Aberrant P-cadherin expression is associated to aggressive feline mammary carcinomas.BMC veterinary research · 2014Article
- Integrins and cadherins as therapeutic targets in fibrosis.Frontiers in pharmacology · 2014Review
- Suppression of E-cadherin mediates gallotannin induced apoptosis in Hep G2 hepatocelluar carcinoma cells.International journal of biological sciences · 2014Article
- Ductal barriers in mammary epithelium.Tissue barriers · 2013Review
- Effects of T-cadherin expression on B16F10 melanoma cells.Oncology letters · 2013Article
- Cadherin cell adhesion system in canine mammary cancer: a review.Veterinary medicine international · 2012Article
- P-cadherin expression in feline mammary tissues.Veterinary medicine international · 2012Article
- Tight junctions: a barrier to the initiation and progression of breast cancer?Journal of biomedicine & biotechnology · 2010Review
- Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast.BMC cancer · 2009Article
- Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.Nature cell biology · 2009Article
- P-cadherin and beta-catenin are useful prognostic markers in breast cancer patients; beta-catenin interacts with heat shock protein Hsp27.Cell stress & chaperones · 2008Article
- Breast cancer progression: controversies and consensus in the molecular mechanisms of metastasis and EMT.Journal of mammary gland biology and neoplasia · 2007Article
- P-cadherin expression in breast cancer: a review.Breast cancer research : BCR · 2007Review
- A soluble truncated cadherin induces breast cancer cell apoptosis and growth inhibition.Journal of cancer research and clinical oncology · 2006Article
- Article
- Epigenetic silencing of DSC3 is a common event in human breast cancer.Breast cancer research : BCR · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cadherins are the transmembrane component of adherens junctions found between interacting cells in tissues. The cadherins bind cells to one another in a specific manner and link to the actin cytoskeleton through intracellular catenins. In addition to promoting strong cell-cell adhesion, cadherins appear to initiate and modify intracellular signaling pathways. The loss of E-cadherin function in epithelial cells is thought to be an important step in tumorigenesis. Moreover, anomalous expression of inappropriate cadherins in epithelial cells alters their behavior and may contribute to the tumorigenic phenotype. For breast cancer the decreased expression of E-cadherin alone may have limited value as a prognostic indicator; however, examining the repertoire of cadherins and catenins expressed by tumors may provide useful prognostic information.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.