ReviewJournal of mammary gland biology and neoplasia2001
Proteoglycans: pericellular and cell surface multireceptors that integrate external stimuli in the mammary gland.
Review in Journal of mammary gland biology and neoplasia, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Proteoglycans in Breast Cancer: Friends and Foes.Biomolecules · 2025Review
- The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour.International journal of molecular sciences · 2023Review
- The Mammary Gland: Basic Structure and Molecular Signaling during Development.International journal of molecular sciences · 2022Review
- A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function.International journal of molecular sciences · 2022Article
- Activated HGF-c-Met Axis in Head and Neck Cancer.Cancers · 2017Review
- The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer.Oncogene · 2016Article
- Article
- Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.Investigative ophthalmology & visual science · 2015Article
- Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis.The Journal of biological chemistry · 2014Article
- Heparan sulfate mediates trastuzumab effect in breast cancer cells.BMC cancer · 2013Article
- Heparan sulfate and heparanase as modulators of breast cancer progression.BioMed research international · 2013Review
- Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy.Breast cancer (Dove Medical Press) · 2012Article
- Old and new stories: revelations from functional analysis of the bovine mammary transcriptome during the lactation cycle.PloS one · 2012Article
- Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.Developmental biology · 2011Article
- Cell-matrix interactions in mammary gland development and breast cancer.Cold Spring Harbor perspectives in biology · 2010Review
- Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice.PloS one · 2010Article
- Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt.Pigment cell & melanoma research · 2009Review
- Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans.Cellular and molecular life sciences : CMLS · 2009Review
- Sea urchin arylsulfatase, an extracellular matrix component, is involved in gastrulation during embryogenesis.Development genes and evolution · 2009Article
- Breast tumor microenvironment: proteomics highlights the treatments targeting secretome.Journal of proteome research · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteoglycans consist of a core protein and an associated glycosaminoglycan (GAG) chain of heparan sulfate, chondroitin sulfate, dermatan sulfate or keratan sulfate, which are attached to a serine residue. The core proteins of cell surface proteoglycans may be transmembrane, e.g., syndecan, or GPI-anchored, e.g., glypican. Many different cell surface and matrix proteoglycan core proteins are expressed in the mammary gland and in mammary cells in culture. The level of expression of these core proteins, the structure of their GAG chains, and their degradation are regulated by many of the effectors that control the development and function of the mammary gland. Regulatory proteins of the mammary gland that bind GAG include many growth factors and morphogens (fibroblast growth factors, hepatocyte growth factor/scatter factor, members of the midkine family, wnts), matrix proteins (collagen, fibronectin, and laminin), enzymes (lipoprotein lipase) and microbial surface proteins. Structural diversity within GAG chains ensures that each protein-GAG interaction is as specific as necessary and a number of sequences of saccharides that recognize individual proteins have been elucidated. The GAG-protein interactions serve to regulate the signal output of growth factor receptor tyrosine kinase and hence cell fate as well as the storage and diffusion of extracellular protein effectors. In addition, GAGs clearly coordinate stromal and epithelial development, and they are active participants in mediating cell-cell and cell-matrix interactions. Since a single proteoglycan, even if it carries a single GAG chain, can bind multiple proteins, proteoglycans are also likely to act as multireceptors which promote the integration of cellular signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.