ArticleMediators of inflammation2001
Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions.
Article in Mediators of inflammation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 43 citations in OpenAlex.
- Crotoxin fromFrontiers in immunology · 2026Article
- Oral Nano-Delivery of Crotoxin Modulates Experimental Ulcerative Colitis in a Mouse Model of Maximum Acute Inflammatory Response.International journal of molecular sciences · 2025Article
- Article
- Pathophysiological and Clinical Significance ofToxins · 2023Article
- Correlating biological activity to thermo-structural analysis of the interaction of CTX with synthetic models of macrophage membranes.Scientific reports · 2021Article
- Effects of venoms on neutrophil respiratory burst: a major inflammatory function.The journal of venomous animals and toxins including tropical diseases · 2021Review
- Review
- Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids.Biomolecules · 2020Article
- Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom.PloS one · 2020Article
- Article
- Crotoxin Isolated fromJournal of immunology research · 2018Article
- Crotoxin from Crotalus durissus terrificus is able to down-modulate the acute intestinal inflammation in mice.PloS one · 2015Article
- Crotalus durissus collilineatus Venom Induces TNF- α and IL-10 Production in Human Peripheral Blood Mononuclear Cells.ISRN inflammation · 2014Article
- S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase.Biochimica et biophysica acta · 2013Review
- Modulation of the pharmacological activities of secretory phospholipase A2 from Crotalus durissus cascavella induced by naringin.Molecules (Basel, Switzerland) · 2011Article
- Pro- and anti-inflammatory cytokines release in mice injected with Crotalus durissus terrificus venom.Mediators of inflammation · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrotoxin (CTX) is a potent neurotoxin from Crotalus durissus terrificus snake venom (CdtV) composed of two subunits: one without catalytic activity (crotapotin), and a basic phospolipase A2. Recent data have demonstrated that CdtV or CTX inhibit some immune and inflammatory reactions.
aimThe aim of this paper was to investigate the mechanisms involved in these impaired responses. MATERIALS AND
methodsMale Swiss mice were bled before and at different intervals of time after subcutaneous injection of CTX or bovine serum albumin (BSA) (control animals). The effect of treatments on circulating leukocyte mobilisation and on serum levels of interleukin (IL)-6, IL-10, interferon (IFN)-gamma and corticosterone were investigated. Spleen cells from treated animals were also stimulated in vitro with concanavalin A to evaluate the profile of IL-4, IL-6, IL-10 or IFN-gamma secretion. Cytokine levels were determined by immunoenzymatic assay and corticosterone levels by radioimmunoassay. To investigate the participation of endogenous corticosteroid on the effects evoked by CTX, animals were treated with metyrapone, an inhibitor of glucocorticoid synthesis, previous to CTX treatment.
resultsMarked alterations on peripheral leukocyte distribution, characterised by a drop in the number of lymphocytes and monocytes and an increase in the number of neutrophils, were observed after CTX injection. No such alteration was observed in BSA-treated animals. Increased levels of IL-6, IL-10 and corticosterone were also detected in CTX-injected animals. IFN-gamma levels were not modified after treatments. In contrast, spleen cells obtained from CTX-treated animals and stimulated with concanavalin A secreted less IL-10 and IL-4 in comparison with cells obtained from control animals. Metyrapone pretreatment was effective only to reverse the neutrophilia observed after CTX administration.
conclusionsOur results suggest that CTX may contribute to the deficient inflammatory and immune responses induced by crude CdtV. CTX induces endogenous mechanisms that are responsible, at least in part, for these impaired responses.
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