ArticleTransplantation2001
Liver transplantation for alcoholic cirrhosis: long term follow-up and impact of disease recurrence.
Article in Transplantation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation.Hepatology international · 2024Guideline
- Pooled it
- Alcohol relapse and its predictors after liver transplantation for alcoholic liver disease: a systematic review and meta-analysis.BMC gastroenterology · 2019Pooled it
- Predictors of Alcohol Relapse Following Liver Transplantation for Alcohol-Induced Liver Failure. Consideration of "A-D" Selection Criteria.Annals of transplantation · 2018Pooled it
- [Psychiatric assessment of alcoholic patients on a waiting list for liver transplantation: which prognostic criteria are empirically proven?].Der Nervenarzt · 2013Pooled it
- Risk factors of adult recipient survival beyond 20 years since liver transplantation: retrospective cohort study.Hepatology international · 2026Article
- Frontiers and Controversies in De Novo Gastrointestinal Tumors After Organ Transplantation: Current Progress and Future Directions.Annals of surgical oncology · 2025Review
- Ethical and allocation issues in liver transplant candidates with alcohol related liver disease.Translational gastroenterology and hepatology · 2022Review
- Alcohol use disorder and liver transplant: new perspectives and critical issues.The Korean journal of internal medicine · 2020Review
- Post-transplant malignancies in alcoholic liver disease.Translational gastroenterology and hepatology · 2020Review
- Superior Wait-List Outcomes in Patients with Alcohol-Associated Liver Disease Compared With Other Indications for Liver Transplantation.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2019Article
- Decision tree analysis to stratify risk of de novo non-melanoma skin cancer following liver transplantation.Journal of cancer research and clinical oncology · 2018Article
- Revisiting the '6-month' liver transplant rule for alcohol-associated liver disease: It is time for a change but not without a sound policy first.Canadian liver journal · 2018Article
- Risk Factors and Outcomes of De Novo Cancers (Excluding Nonmelanoma Skin Cancer) After Liver Transplantation for Primary Sclerosing Cholangitis.Transplantation · 2017Article
- Korean Patients Undergoing Deceased Donor Liver Transplantation for Alcoholic Liver Disease Have Non-Inferior Survival Outcomes than for Hepatitis B Virus: a Real-World Experience without Minimum Abstinence before Transplantation.Journal of Korean medical science · 2017Article
- Ohio solid organ transplantation consortium criteria for liver transplantation in patients with alcoholic liver disease.World journal of hepatology · 2016Article
- Observational
- An Evaluation of the Usefulness of Extracorporeal Liver Support Techniques in Patients Hospitalized in the ICU for Severe Liver Dysfunction Secondary to Alcoholic Liver Disease.Hepatitis monthly · 2016Article
- Lower relapse rates with good post-transplant outcome in alcoholic liver disease: Experience from a living donor liver transplant center.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Article
- Neoplastic disease after liver transplantation: Focus on de novo neoplasms.World journal of gastroenterology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAlcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is a controversial use of resources. We aimed to examine all aspects of liver transplantation associated with alcohol abuse.
methodsRetrospective cohort analysis of 123 alcoholic patients with a median of 7 years follow-up at one center.
resultsIn addition to alcohol, 43 (35%) patients had another possible factor contributing to cirrhosis. Actuarial patient and graft survival rates were, respectively, 84% and 81% (1 year); 72% and 66% (5 years); and 63% and 59% (7 years). After transplantation, 18 patients (15%) manifested 21 noncutaneous de novo malignancies, which is significantly more than controls (P=0.0001); upper aerodigestive squamous carcinomas were overrepresented (P=0.03). Thirteen patients had definitely relapsed and three others were suspected to have relapsed. Relapse was predicted by daily ethanol consumption (P=0.0314), but not by duration of pretransplant sobriety or explant histology. No patient had alcoholic hepatitis after transplantation and neither late onset acute nor chronic rejection was significantly increased. Multiple regression analyses for predictors of graft failure identified major biliary/vascular complications (P=0.01), chronic bile duct injury on biopsy (P=0.002), and pericellular fibrosis on biopsy (P=0.05); graft viral hepatitis was marginally significant (P=0.07) on univariate analysis.
conclusionsAlcoholic liver disease is an excellent indication for liver transplantation in those without coexistent conditions. Recurrent alcoholic liver disease alone is not an important cause of graft pathology or failure. Potential recipients should be heavily screened before transplantation for coexistent conditions (e.g., hepatitis C, metabolic diseases) and other target-organ damage, especially aerodigestive malignancy, which are greater causes of morbidity and mortality than is recurrent alcohol liver disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.