ArticleJournal of immunology (Baltimore, Md. : 1950)2001
An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16European journal of immunology · 2026Article
- CD151 Expression Is Associated with a Hyperproliferative T Cell Phenotype.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis.Oncotarget · 2016Article
- Contribution of B-1a cells to systemic lupus erythematosus in the NZM2410 mouse model.Annals of the New York Academy of Sciences · 2015Review
- CD28 co-stimulation in T-cell homeostasis: a recent perspective.ImmunoTargets and therapy · 2015Review
- Regulation of T cell differentiation and alloimmunity by the cyclin-dependent kinase inhibitor p18ink4c.PloS one · 2014Article
- Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cyclin-dependent kinase inhibitor Cdkn2c deficiency promotes B1a cell expansion and autoimmunity in a mouse model of lupus.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Cyclin dependent kinase inhibitors differentially modulate synergistic cytokine responsiveness of hematopoietic progenitor cells.Stem cells and development · 2012Article
- An opposite effect of the CDK inhibitor, p18(INK4c) on embryonic stem cells compared with tumor and adult stem cells.PloS one · 2012Article
- Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence.Cancer research · 2012Article
- First insight into the kinome of human regulatory T cells.PloS one · 2012Article
- Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2010Article
- Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice.The Journal of biological chemistry · 2008Article
- TSLP is involved in expansion of early thymocyte progenitors.BMC immunology · 2007Article
- FoxP3 enhances HIV-1 gene expression by modulating NFkappaB occupancy at the long terminal repeat in human T cells.The Journal of biological chemistry · 2007Article
- Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance.Seminars in immunology · 2007Review
- Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis.Cell division · 2007Article
- Paradoxical expression of INK4c in proliferative multiple myeloma tumors: bi-allelic deletion vs increased expression.Cell division · 2006Article
- Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP.BMC immunology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 3 countries.
Funding
Abstract
The inhibitors of cyclin-dependent kinase (CDK) 4 (INK4) bind CDK4/6 to prevent their association with D-cyclins and G(1) cell cycle initiation and progression. We report here that among the seven CDK inhibitors, p18(INK4c) played an important role in modulating TCR-mediated T cell proliferation. Loss of p18(INK4c) in T cells led to hyperproliferation in response to CD3 stimulation. p18(INK4c)-null mice developed lymphoproliferative disorder and T cell lymphomas. Expression of IL-2, IL-2R-alpha, and the major G(1) cell cycle regulatory proteins was not altered in p18-null T cells. Both FK506 and rapamycin efficiently inhibited proliferation of p18-null T cells. In activated T cells, p18(INK4c) remained constant, and preferentially associated with and inhibited CDK6 but not CDK4. We propose that p18(INK4c) sets an inhibitory threshold in T cells and one function of CD28 costimulation is to counteract the p18(INK4c) inhibitory activity on CDK6-cyclin D complexes. The p18(INK4c) protein may provide a novel target to modulate T cell immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.