ArticleGenes & development2001
A homeotic mutation in the trithorax SET domain impedes histone binding.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Review
- Epigenetic disorders: Lessons from the animals-animal models in chromatinopathies.Frontiers in cell and developmental biology · 2022Review
- HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development.Cell reports · 2016Article
- Binding of plasma proteins to titanium dioxide nanotubes with different diameters.International journal of nanomedicine · 2015Article
- A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.Journal of molecular biology · 2014Article
- WRAD: enabler of the SET1-family of H3K4 methyltransferases.Briefings in functional genomics · 2012Review
- The super elongation complex (SEC) and MLL in development and disease.Genes & development · 2011Review
- Interaction of SET domains with histones and nucleic acid structures in active chromatin.Clinical epigenetics · 2011Article
- Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression.PloS one · 2011Article
- Histone H3 lysine 4 (H3K4) methylation in development and differentiation.Developmental biology · 2010Review
- Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes.Molecular and cellular biology · 2010Article
- SET domains of histone methyltransferases recognize ISWI-remodeled nucleosomal species.Molecular and cellular biology · 2010Article
- ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation.The Plant cell · 2008Article
- The Arabidopsis SET-domain protein ASHR3 is involved in stamen development and interacts with the bHLH transcription factor ABORTED MICROSPORES (AMS).Plant molecular biology · 2008Article
- Histone modification and the control of heterochromatic gene silencing in Drosophila.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Review
- The Arabidopsis SUVR4 protein is a nucleolar histone methyltransferase with preference for monomethylated H3K9.Nucleic acids research · 2006Article
- MLL associates specifically with a subset of transcriptionally active target genes.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes.Molecular and cellular biology · 2005Article
- Set1 is required for meiotic S-phase onset, double-strand break formation and middle gene expression.The EMBO journal · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trithorax (TRX) is a Drosophila SET domain protein that is required for the correct expression of homeotic genes. Here, we show that the TRX SET domain efficiently binds to core histones and nucleosomes. The primary target for the SET domain is histone H3 and binding requires the N-terminal histone tails. The previously described trx(Z11) mutation changes a strictly conserved glycine in the SET domain to serine and causes homeotic transformations in the fly. We found that this mutation selectively interferes with histone binding, suggesting that histones represent a critical target during developmental gene regulation by TRX.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.