ReviewEnvironmental health perspectives2001
Inflammation-induced plasticity of the afferent innervation of the airways.
Review in Environmental health perspectives, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- Review
- Characterization of Early Inflammatory Events Leading to Provoked Vulvodynia Development in Rats.Journal of inflammation research · 2022Article
- Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease.Journal of leukocyte biology · 2022Review
- NGF and Its Receptors in the Regulation of Inflammatory Response.International journal of molecular sciences · 2017Review
- Impact of Air Pollution on Age and Gender Related Increase in Cough Reflex Sensitivity of Healthy Children in Slovakia.Frontiers in physiology · 2016Article
- Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS.BioMed research international · 2015Article
- Neurogenic airway inflammation induced by repeated intra-esophageal instillation of HCl in guinea pigs.Inflammation · 2013Article
- Inhibition of airway hyper-responsiveness by TRPV1 antagonists (SB-705498 and PF-04065463) in the unanaesthetized, ovalbumin-sensitized guinea pig.British journal of pharmacology · 2012Article
- Direct and indirect effects of particulate matter on the cardiovascular system.Toxicology letters · 2012Review
- Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- KCa1.1 channel contributes to cell excitability in unmyelinated but not myelinated rat vagal afferents.American journal of physiology. Cell physiology · 2011Article
- Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal.The Journal of physiology · 2008Article
- Review
- Review
- TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs.Cough (London, England) · 2006Article
- Effects of intravenous lidocaine prior to intubation on postoperative airway symptoms.Journal of anesthesia · 2006Article
- Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health.Environmental health perspectives · 2005Review
- Symptomatic effects of exposure to diluted air sampled from a swine confinement atmosphere on healthy human subjects.Environmental health perspectives · 2005Article
- Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.British journal of pharmacology · 2003Article
- The role of nerves in asthma.Current allergy and asthma reports · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activation of primary afferent neurons that innervate the airways leads to homeostatic and defensive reflexes. The anatomic and physiologic characteristics of these afferent fibers do not appear to be static properties but rather appear to change rapidly in response to inflammation. The threshold for activation of airway afferent neurons to various stimuli, for example, is not fixed; these fibers can be become sensitized during inflammation. A subset of nociceptive-like (C-fibers) airway afferent neurons not only participates in centrally mediated reflexes but is also thought to release neuropeptides at their peripheral terminals, leading to neurogenic inflammation. An increase in the content of tachykinins is commonly seen in inflamed tissues, and there is accumulating evidence that irritation and inflammation of the airways is associated with the induction of tachykinin synthesis in non-nociceptive airway afferent fibers that under normal conditions do not contain neuropeptides. The release of neurokinins from the peripheral terminals in the airways and their central terminals in the brain stem may contribute to the symptoms of inflammatory airway diseases. Elevated release of neurokinins from peripheral terminals may promote local inflammatory responses, and the release of neurokinins in the brainstem, together with inflammation-induced increases in the excitability of afferent fibers, may culminate in altered visceral autonomic reflex activity, changes in breathing pattern, and cough.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.