ArticleJournal of molecular evolution1994
The use of gel electrophoresis to study the reactions of activated amino acids with oligonucleotides.
Article in Journal of molecular evolution, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Substrate-directed formation of small biocatalysts under prebiotic conditions.Journal of molecular evolution · 1997Article
- Catalysis of the oligomerization of O-phospho-serine, aspartic acid, or glutamic acid by cationic micelles.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 1996Article
- Oligonucleotides as probes for studying polymerization reactions in dilute aqueous solution: II. Polycondensations.Journal of molecular evolution · 1995Article
- Oligonucleotides as probes for studying polymerization reactions in dilute aqueous solution.Journal of molecular evolution · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used gel electrophoresis to study the primary covalent addition of amino acids to oligonucleotides or their analogs and the subsequent addition of further molecules of the amino acids to generate peptides covalently linked to the oligonucleotides. We have surveyed the reactions of a variety of amino acids with the phosphoramidates derived from oligonucleotide 5'-phosphates and ethylenediamine. We find that arginine and amino acids that can interact with oligonucleotides through stacking interactions react most efficiently. D- and L-amino acids give indistinguishable families of products.
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Registered trials
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