ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life1997
Modelling of the prebiotic synthesis of oligopeptides: silicate catalysts help to overcome the critical stage.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 54 citations in OpenAlex.
- The Effect of Goethites on the Polymerization of Glycine and Alanine Under Prebiotic Chemistry Conditions.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
- Trimetaphosphate Activates Prebiotic Peptide Synthesis across a Wide Range of Temperature and pH.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
- Thermal Condensation of Glycine and Alanine on Metal Ferrite Surface: Primitive Peptide Bond Formation Scenario.Life (Basel, Switzerland) · 2017Article
- Formation of Diastereoisomeric Piperazine-2,5-dione from DL-Alanine in the Presence of Olivine and Water.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2017Article
- Biomineralization: a proposed evolutionary origin for inorganic cofactors of enzymes.Theory in biosciences = Theorie in den Biowissenschaften · 2012Article
- Oligomerization of glycine and alanine catalyzed by iron oxides: implications for prebiotic chemistry.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2012Article
- Mineral surfaces, geochemical complexities, and the origins of life.Cold Spring Harbor perspectives in biology · 2010Review
- Adsorption and polymerization of amino acids on mineral surfaces: a review.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2008Review
- Amino acid interaction with and adsorption on clays: FT-IR and Mössbauer spectroscopy and X-ray diffractometry investigations.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2007Article
- The origin and emergence of life under impact bombardment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Article
- Biochemical evolution. I. Polymerization On internal, organophilic silica surfaces of dealuminated zeolites and feldspars.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
On the basis of experimental studies of the initial stages of glycine oligomerization in aqueous suspension of zeolite and kaolinite catalysts, a model is suggested for the prebiotic synthesis of oligopeptides from alpha-amino acids. The formation of linear dipeptides by hydrolysis of one amide bond in the cyclic piperazinedione intermediate (formed from glycine spontaneously) is found to be the critical stage of the reaction. This stage is base catalyzed and its rate increases when pH of the medium goes up. The linear glycyl-glycine yield rises under effect of hydroxyl anions generated from different sources including insoluble silicates and soluble sodium bicarbonate. During prebiotic evolution silicates capable of cation-exchange can serve as local sources of the hydroxyl anions which dramatically accelerate formation of linear dipeptides from cyclic ones. Oligopeptides of higher molecular weight are then easily formed from the linear dipeptides at neutral pH, even in the absence of catalysts or sources of energy (e.g. such as light). The described catalytic synthesis could occur in the proximity of submarine hydrothermal vents.
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