ArticleProceedings of the National Academy of Sciences of the United States of America2001
Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 88 citations in OpenAlex.
- Genetic mapping of determinants in drug resistance, virulence, disease susceptibility, and interaction of host-rodent malaria parasites.Parasitology international · 2022Review
- Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022Review
- Mouse NC/Jic strain provides novel insights into host genetic factors for malaria research.Experimental animals · 2019Review
- Host genetics in malaria: lessons from mouse studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria.PloS one · 2017Article
- Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.Malaria journal · 2016Article
- Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population.PloS one · 2015Article
- Article
- A cautionary note on ignoring polygenic background when mapping quantitative trait loci via recombinant congenic strains.Frontiers in genetics · 2014Article
- Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9.Malaria journal · 2013Article
- Genetic control of high density lipoprotein-cholesterol in AcB/BcA recombinant congenic strains of mice.Physiological genomics · 2012Article
- Genetic control of susceptibility to infection with Plasmodium chabaudi chabaudi AS in inbred mouse strains.Genes and immunity · 2012Article
- The contribution of Plasmodium chabaudi to our understanding of malaria.Trends in parasitology · 2012Review
- Multigenic control and sex bias in host susceptibility to spore-induced pulmonary anthrax in mice.Infection and immunity · 2011Article
- Host resistance to malaria: using mouse models to explore the host response.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.Experimental parasitology · 2010Article
- Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin.Antimicrobial agents and chemotherapy · 2010Article
- Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival.PloS one · 2010Article
- Loss of ability to self-heal malaria upon taurine transporter deletion.Infection and immunity · 2010Article
- Mapping of Char10, a novel malaria susceptibility locus on mouse chromosome 9.Genes and immunity · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The genetic component of susceptibility to malaria is complex, both in humans and in the mouse model of infection. Two murine loci on chromosomes 8 (Pchr/Char2) and 9 (Char1) have previously been mapped in F(2) crosses, and play an important role in regulating blood parasitemia and survival to infection with Plasmodium chabaudi. These loci explain only part of the interstrain phenotypic variance, and their penetrance and expressivity vary in different inbred strains. Novel loci regulating response to P. chabaudi infection were investigated by using an alternative strategy based on a newly derived set of AcB/BcA recombinant congenic strains bred from malaria-susceptible A/J (A) and resistant C57BL/6J (B6). One of the AcB strains, AcB55, is shown to be highly resistant to infection despite 83% susceptible A genomic composition, including susceptibility alleles at Char1 and Pchr/Char2. Early onset of parasite clearance in AcB55 is associated with lower peak parasitemia and absence of mortality. Linkage analysis in an informative (AcB55 x A)F(2) population, using peak parasitemia as a quantitative trait, located a new B6-derived resistance locus on chromosome 3 (lod score = 6.57) that we designate Char4. A second, suggestive linkage on chromosome 10 (lod score = 2.53) shows additive effect with Char4 on peak parasitemia. Char4 maps to a small congenic B6 fragment in AcB55 that should facilitate the search for candidate genes. Our findings provide an entry point for parallel association studies in humans between the syntenic 4q21-4q25 region and susceptibility to disease in endemic areas of malaria.
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