ArticleProceedings of the National Academy of Sciences of the United States of America2001
History dependence of protein adsorption kinetics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Soft Interferometric Nanostrain Sensor Reveals Solid-Liquid Interfacial Tension Oscillation Amplified by Competitive Adsorption.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Electrode Potential-Dependent Studies of Protein Adsorption on TiMolecules (Basel, Switzerland) · 2023Article
- Quantitative Comparison of Protein Adsorption and Conformational Changes on Dielectric-Coated Nanoplasmonic Sensing Arrays.Sensors (Basel, Switzerland) · 2018Article
- Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator.Journal of the American Chemical Society · 2017Article
- Sequential and competitive adsorption of peptides at pendant PEO layers.Colloids and surfaces. B, Biointerfaces · 2015Article
- Effect of the interplay between protein and surface on the properties of adsorbed protein layers.Biomaterials · 2014Article
- A bottom-up approach to understanding protein layer formation at solid-liquid interfaces.Advances in colloid and interface science · 2014Review
- Interfacial protein-protein associations.Biomacromolecules · 2014Article
- Measuring memory with the order of fractional derivative.Scientific reports · 2013Article
- Adsorption, structural alteration and elution of peptides at pendant PEO layers.Colloids and surfaces. B, Biointerfaces · 2013Article
- Structural attributes affecting peptide entrapment in PEO brush layers.Colloids and surfaces. B, Biointerfaces · 2013Article
- Quantifying nisin adsorption behavior at pendant PEO layers.Journal of colloid and interface science · 2013Article
- Closer look at the operating definition of protein recovery in CE.Electrophoresis · 2013Article
- Optical waveguide lightmode spectroscopy (OWLS) as a sensor for thin film and quantum dot corrosion.Sensors (Basel, Switzerland) · 2012Article
- Nisin adsorption to hydrophobic surfaces coated with the PEO-PPO-PEO triblock surfactant Pluronic F108.Journal of colloid and interface science · 2008Article
- Fibronectin terminated multilayer films: protein adsorption and cell attachment studies.Biomaterials · 2007Article
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3 authors.
Funding
Abstract
The behavior of proteins at biological and synthetic interfaces is often characterized by a strong history dependence caused by long relaxation times or irreversible transitions. In this work, we introduce the rate of adsorption as a means to systematically quantify the extent, and identify the underlying causes, of history dependence. We use multistep kinetic experiments in which the i'th step is an exposure of a Si(Ti)O(2) surface to a flowing fibronectin or cytochrome c solution of concentration c(i) for a time t(i) (c(i) = 0 corresponds to a rinse) and measure the protein adsorption by optical waveguide light mode spectroscopy. The rate of adsorption is sensitive to the structure of the adsorbed layer, and we observe it to greatly increase, for a given adsorbed density, when going from a first to a subsequent adsorption step. This increase is most pronounced when the duration of the initial adsorption step is long. We attribute these observations to the gradual and irreversible formation of protein clusters or locally ordered structures and use them to explain previous underestimates of kinetic data by mesoscopic model descriptions. A thorough understanding of these complex postadsorption events, and their impact on history dependence, is essential for many physiological and biotechnological processes. Optical waveguide lightmode spectroscopy is a promising technique for their macroscopic quantification.
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