ArticleJournal of neurophysiology2001
NMDA antagonists in the superior colliculus prevent developmental plasticity but not visual transmission or map compression.
Article in Journal of neurophysiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Age-Related Changes in Temporal Binding Involving Auditory and Vestibular Inputs.Seminars in hearing · 2024Review
- Capturing a rising star: the emerging role of astrocytes in neural circuit wiring and plasticity-lessons from the visual system.Neurophotonics · 2023Review
- The effects of the NMDAR co-agonist D-serine on the structure and function of optic tectal neurons in the developing visual system.Scientific reports · 2023Article
- Article
- Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment.Current topics in developmental biology · 2021Review
- Dynamic Alterations of Retinal EphA5 Expression in Retinocollicular Map Plasticity.Developmental neurobiology · 2019Article
- The Impact of Ecological Niche on Adaptive Flexibility of Sensory Circuitry.Frontiers in neuroscience · 2017Review
- Rules for Shaping Neural Connections in the Developing Brain.Frontiers in neural circuits · 2016Review
- On the Role of Glutamate in Presynaptic Development: Possible Contributions of Presynaptic NMDA Receptors.Biomolecules · 2015Review
- The impact of development and sensory deprivation on dendritic protrusions in the mouse barrel cortex.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Resonant Cholinergic Dynamics in Cognitive and Motor Decision-Making: Attention, Category Learning, and Choice in Neocortex, Superior Colliculus, and Optic Tectum.Frontiers in neuroscience · 2015Article
- Allocating structure to function: the strong links between neuroplasticity and natural selection.Frontiers in human neuroscience · 2014Article
- Regulation of ephrin-A expression in compressed retinocollicular maps.Developmental neurobiology · 2013Article
- Facilitation of neocortical presynaptic terminal development by NMDA receptor activation.Neural development · 2012Article
- Functional elimination of excitatory feedforward inputs underlies developmental refinement of visual receptive fields in zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling.The Journal of physiology · 2010Review
- Article
- Action-based body maps in the spinal cord emerge from a transitory floating organization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Mechanisms underlying development of visual maps and receptive fields.Annual review of neuroscience · 2008Review
- Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Partial ablation of the superior colliculus (SC) at birth in hamsters compresses the retinocollicular map, increasing the amount of visual field represented at each SC location. Receptive field sizes of single SC neurons are maintained, however, preserving receptive field properties in the prelesion condition. The mechanism that allows single SC neurons to restrict the number of convergent retinal inputs and thus compensate for induced brain damage is unknown. In this study, we examined the role of N-methyl-D-aspartate (NMDA) receptors in controlling retinocollicular convergence. We found that chronic 2-amino-5-phosphonovaleric acid (APV) blockade of NMDA receptors from birth in normal hamsters resulted in enlarged single-unit receptive fields in SC neurons from normal maps and further enlargement in lesioned animals with compressed maps. The effect was linearly related to lesion size. These results suggest that NMDA receptors are necessary to control afferent/target convergence in the normal SC and to compensate for excess retinal afferents in lesioned animals. Despite the alteration in receptive field size in the APV-treated animals, a complete visual map was present in both normal and lesioned hamsters. Visual responsiveness in the treated SC was normal; thus the loss of compensatory plasticity was not due to reduced visual responsiveness. Our results argue that NMDA receptors are essential for map refinement, construction of receptive fields, and compensation for damage but not overall map compression. The results are consistent with a role for the NMDA receptor as a coincidence detector with a threshold, providing visual neurons with the ability to calculate the amount of visual space represented by competing retinal inputs through the absolute amount of coincidence in their firing patterns. This mechanism of population matching is likely to be of general importance during nervous system development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.