ArticleThe Journal of experimental medicine2001
Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 101 citations in OpenAlex.
- EBF1, PAX5, and MYC: regulation on B cell development and association with hematologic neoplasms.Frontiers in immunology · 2024Review
- The Gene Rearrangement and Transcriptional Regulation of Non B Cell-Derived Immunoglobulin.Advances in experimental medicine and biology · 2024Review
- Enhancers within the Ig V Gene Region Orchestrate Chromatin Topology and Regulate V Gene Rearrangement Frequency to Shape the B Cell Receptor Repertoire Specificities.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens.Nature immunology · 2023Article
- Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.Nucleic acids research · 2020Article
- Enhancers as regulators of antigen receptor loci three-dimensional chromatin structure.Transcription · 2020Review
- Helix-loop-helix proteins and the advent of cellular diversity: 30 years of discovery.Genes & development · 2019Review
- Cutting Edge: Proper Orientation of CTCF Sites in Cer Is Required for Normal Jκ-Distal and Jκ-Proximal Vκ Gene Usage.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Aging, cytomegalovirus (CMV) and influenza vaccine responses.Human vaccines & immunotherapeutics · 2016Review
- Obesity decreases B cell responses in young and elderly individuals.Obesity (Silver Spring, Md.) · 2016Article
- E proteins in lymphocyte development and lymphoid diseases.Current topics in developmental biology · 2014Review
- B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1.Current topics in microbiology and immunology · 2012Review
- Id1 has a physiological role in regulating early B lymphopoiesis.Cellular & molecular immunology · 2011Article
- Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells.PloS one · 2011Article
- The center of accessibility: Dβ control of V(D)J recombination.Archivum immunologiae et therapiae experimentalis · 2010Review
- Regulation of antigen receptor gene assembly by genetic-epigenetic crosstalk.Seminars in immunology · 2010Review
- Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes.Seminars in immunology · 2010Review
- E proteins and the regulation of early lymphocyte development.Immunological reviews · 2010Review
- Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci.The Journal of experimental medicine · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Accessibility of immunoglobulin (Ig) gene segments to V(D)J recombination is highly regulated and is normally only achieved in B cell precursors. We previously showed that ectopic expression of E2A or early B cell factor (EBF) with recombination activating gene (RAG) induces rearrangement of IgH and IgL genes in nonlymphoid cells. VkappaI genes throughout the locus were induced to rearrange after transfection with E2A, suggesting that the entire Vkappa locus was accessible. However, here we show that Ig loci are not opened globally but that recombination is localized. Gene families are interspersed in the D(H), Vkappa, and Vlambda loci, and we show that certain families and individual genes undergo high levels of recombination after ectopic expression of E2A or EBF, while other families within the same locus are not induced to rearrange. Furthermore, in some families, induction of germline transcription correlates with the level of induced recombination, while in others there is no correlation, suggesting that recombination is not simply initiated by induction of germline transcription. The induced repertoire seen at 24 hours does not change significantly over time indicating the absence of many secondary rearrangements and also suggesting a direct targeting mechanism. We propose that accessibility occurs in a local manner, and that binding sites for factors facilitating accessibility are therefore likely to be associated with individual gene segments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.