ArticleMolecular and cellular biology2001
Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 87 citations in OpenAlex.
- Genome-wide identification and expression analysis of Wnt gene family in the forest musk deer (Moschus berezovskii) under musk secretion stage.BMC genomics · 2025Article
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- Hypothyroidism and Cognitive Disorders during Development and Adulthood: Implications in the Central Nervous System.Molecular neurobiology · 2019Review
- Review
- The effects of vitamin C on hypothyroidism-associated learning and memory impairment in juvenile rats.Metabolic brain disease · 2017Article
- Article
- Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice.Endocrinology · 2016Article
- Brain Tissues Oxidative Damage as A Possible Mechanism of Deleterious Effects of Propylthiouracil- Induced Hypothyroidism on Learning and Memory in Neonatal and Juvenile Growth in Rats.Basic and clinical neuroscience · 2014Article
- Wnt and lithium: a common destiny in the therapy of nervous system pathologies?Cellular and molecular life sciences : CMLS · 2014Review
- An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autism.Frontiers in endocrinology · 2014Review
- Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.Cell · 2013Article
- Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling.The Journal of biological chemistry · 2012Article
- Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).The Journal of biological chemistry · 2011Article
- Studies of complex biological systems with applications to molecular medicine: the need to integrate transcriptomic and proteomic approaches.Journal of biomedicine & biotechnology · 2011Review
- Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway.Experimental cell research · 2010Review
- Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire.Oncogene · 2009Article
- Isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.Endocrinology · 2008Article
- Role of GAC63 in transcriptional activation mediated by beta-catenin.Nucleic acids research · 2007Article
- Liver stem cells and molecular signaling pathways in hepatocellular carcinoma.Gastrointestinal cancer research : GCR · 2007Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
To investigate the transcriptional program underlying thyroid hormone (T3)-induced cell proliferation, cDNA microarrays were used to survey the temporal expression profiles of 4,400 genes. Of 358 responsive genes identified, 88% had not previously been reported to be transcriptionally or functionally modulated by T3. Partitioning the genes into functional classes revealed the activation of multiple pathways, including glucose metabolism, biosynthesis, transcriptional regulation, protein degradation, and detoxification in T3-induced cell proliferation. Clustering the genes by temporal expression patterns provided further insight into the dynamics of T3 response pathways. Of particular significance was the finding that T3 rapidly repressed the expression of key regulators of the Wnt signaling pathway and suppressed the transcriptional downstream elements of the beta-catenin-T-cell factor complex. This was confirmed biochemically, as beta-catenin protein levels also decreased, leading to a decrease in the transcriptional activity of a beta-catenin-responsive promoter. These results indicate that T3-induced cell proliferation is accompanied by a complex coordinated transcriptional reprogramming of many genes in different pathways and that early silencing of the Wnt pathway may be critical to this event.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.