ArticleMolecular and cellular biology2001
Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 90 citations in OpenAlex.
- TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells.iScience · 2023Article
- Towards the Mechanism of Yeast Telomere Dynamics.Trends in cell biology · 2019Review
- Mild Telomere Dysfunction as a Force for Altering the Adaptive Potential of Subtelomeric Genes.Genetics · 2018Article
- TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.Nature communications · 2016Article
- Hypothesis: Paralog Formation from Progenitor Proteins and Paralog Mutagenesis Spur the Rapid Evolution of Telomere Binding Proteins.Frontiers in genetics · 2016Article
- A single-cell assay for telomere DNA content shows increasing telomere length heterogeneity, as well as increasing mean telomere length in human spermatozoa with advancing age.Journal of assisted reproduction and genetics · 2015Article
- The many facets of homologous recombination at telomeres.Microbial cell (Graz, Austria) · 2015Review
- SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates.Nucleic acids research · 2015Article
- Identification of Plasmodium falciparum DNA Repair Protein Mre11 with an Evolutionarily Conserved Nuclease Function.PloS one · 2015Article
- The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.PloS one · 2014Article
- Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end.Genetics · 2012Review
- RTEL1 contributes to DNA replication and repair and telomere maintenance.Molecular biology of the cell · 2012Article
- Overcoming natural replication barriers: differential helicase requirements.Nucleic acids research · 2012Article
- Long telomeres produced by telomerase-resistant recombination are established from a single source and are subject to extreme sequence scrambling.PLoS genetics · 2012Article
- Recombination can either help maintain very short telomeres or generate longer telomeres in yeast cells with weak telomerase activity.Eukaryotic cell · 2011Article
- Recombination can cause telomere elongations as well as truncations deep within telomeres in wild-type Kluyveromyces lactis cells.Eukaryotic cell · 2011Article
- Differential maintenance of DNA sequences in telomeric and centromeric heterochromatin.Genetics · 2011Article
- Taming the tiger by the tail: modulation of DNA damage responses by telomeres.The EMBO journal · 2009Review
- Telomere maintenance and survival in saccharomyces cerevisiae in the absence of telomerase and RAD52.Genetics · 2009Article
- Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres.Human molecular genetics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have previously identified a process in the yeast Saccharomyces cerevisiae that results in the contraction of elongated telomeres to wild-type length within a few generations. We have termed this process telomeric rapid deletion (TRD). In this study, we use a combination of physical and genetic assays to investigate the mechanism of TRD. First, to distinguish among several recombinational and nucleolytic pathways, we developed a novel physical assay in which HaeIII restriction sites are positioned within the telomeric tract. Specific telomeres were subsequently tested for HaeIII site movement between telomeres and for HaeIII site retention during TRD. Second, genetic analyses have demonstrated that mutations in RAD50 and MRE11 inhibit TRD. TRD, however, is independent of the Rap1p C-terminal domain, a central regulator of telomere size control. Our results provide evidence that TRD is an intrachromatid deletion process in which sequences near the extreme terminus invade end-distal sequences and excise the intervening sequences. We propose that the Mre11p-Rad50p-Xrs2p complex prepares the invading telomeric overhang for strand invasion, possibly through end processing or through alterations in chromatin structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.