ArticleJournal of virology2001
Receptor binding transforms the surface subunit of the mammalian C-type retrovirus envelope protein from an inhibitor to an activator of fusion.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
- Conserved residues of the immunosuppressive domain of MLV are essential for regulating the fusion-critical SU-TM disulfide bond.Journal of virology · 2024Article
- Deep-Time Structural Evolution of Retroviral and Filoviral Surface Envelope Proteins.Journal of virology · 2022Article
- The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex.Journal of virology · 2014Article
- Phylogenetic and biological analysis of a laboratory-generated gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV).Virus genes · 2012Article
- JNK1 is required for lentivirus entry and gene transfer.Journal of virology · 2011Article
- Naturally Occurring Polymorphisms of the Mouse Gammaretrovirus Receptors CAT-1 and XPR1 Alter Virus Tropism and Pathogenicity.Advances in virology · 2011Article
- Murine leukemia viruses: objects and organisms.Advances in virology · 2011Article
- Turning of the receptor-binding domains opens up the murine leukaemia virus Env for membrane fusion.The EMBO journal · 2008Article
- Intersubunit disulfide isomerization controls membrane fusion of human T-cell leukemia virus Env.Journal of virology · 2008Article
- Feline leukemia virus T entry is dependent on both expression levels and specific interactions between cofactor and receptor.Virology · 2007Article
- Molecular gymnastics at the herpesvirus surface.EMBO reports · 2006Review
- Envelope determinants for dual-receptor specificity in feline leukemia virus subgroup A and T variants.Journal of virology · 2006Article
- Dissection of gammaretroviral receptor function by using type III phosphate transporters as models.Journal of virology · 2005Article
- Involvement of the C-terminal disulfide-bonded loop of murine leukemia virus SU protein in a postbinding step critical for viral entry.Journal of virology · 2005Article
- Receptor-induced conformational changes in the SU subunit of the avian sarcoma/leukosis virus A envelope protein: implications for fusion activation.Journal of virology · 2005Article
- The fusion-controlling disulfide bond isomerase in retrovirus Env is triggered by protein destabilization.Journal of virology · 2005Article
- The many mechanisms of viral membrane fusion proteins.Current topics in microbiology and immunology · 2005Review
- Expression and characterization of a soluble, active form of the jaagsiekte sheep retrovirus receptor, Hyal2.Journal of virology · 2005Article
- HTLV-1 and -2 envelope SU subdomains and critical determinants in receptor binding.Retrovirology · 2004Article
- Retroviruses 2004: review of the 2004 Cold Spring Harbor Retroviruses Conference.Retrovirology · 2004Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The envelope protein (Env) of murine leukemia viruses (MLVs) is composed of a surface subunit (SU) and a transmembrane subunit (TM), which mediates membrane fusion, resulting in infection. SU contains a discrete N-terminal receptor binding domain (RBD) that is connected to the remainder of Env by a short, proline-rich segment. Previous studies suggest that after receptor binding, the RBD interacts directly with the remainder of Env to trigger fusion (A. L. Barnett, R. A. Davey, and J. M. Cunningham, Proc. Natl. Acad. Sci. USA 98:4113-4118, 2001). To investigate the role of the RBD in activating fusion, we compared infection by several MLVs that are defective unless rescued in trans by the addition of soluble RBD to the culture medium. Infection by MLV lacking a critical histidine residue near the N terminus of the viral RBD is dependent on the expression of receptors for both the RBD in the viral Env and the soluble RBD supplied in trans. However, infection by MLVs in which the RBD has been deleted or replaced by the ligand erythropoietin are dependent only on expression of the receptor for the soluble RBD. We were able to expand the host range of xenotropic MLV to nonpermissive murine fibroblasts only if the RBD was deleted from the xenotropic viral envelope and the soluble RBD from ecotropic Friend MLV was supplied to the culture medium. These findings indicate that receptor binding transforms the RBD from an inhibitor to an activator of the viral fusion mechanism and that viruses lacking the critical histidine residue at the N terminus of the RBD are impaired at the activation step.
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