ArticleThe Journal of physiology2001
Multiple transport functions of a red blood cell anion exchanger, tAE1: its role in cell volume regulation.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- KScience advances · 2020Article
- KNature · 2017Article
- Structural model of the anion exchanger 1 (SLC4A1) and identification of transmembrane segments forming the transport site.The Journal of biological chemistry · 2013Article
- Calcium in red blood cells-a perilous balance.International journal of molecular sciences · 2013Review
- Dual transport properties of anion exchanger 1: the same transmembrane segment is involved in anion exchange and in a cation leak.The Journal of biological chemistry · 2011Article
- Band 3 missense mutations and stomatocytosis: insight into the molecular mechanism responsible for monovalent cation leak.International journal of cell biology · 2011Article
- A volume regulatory response can be triggered by nucleosides in human erythrocytes, a perfect osmometer no longer.The Journal of biological chemistry · 2010Article
- The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes.American journal of physiology. Cell physiology · 2010Article
- Article
- Chlorella virus ATCV-1 encodes a functional potassium channel of 82 amino acids.The Biochemical journal · 2009Article
- Review. Leaky Cl--HCO3- exchangers: cation fluxes via modified AE1.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
- A conductive pathway generated from fragments of the human red cell anion exchanger AE1.The Journal of physiology · 2007Article
- The activation pathway of the volume-sensitive organic osmolyte channel in Xenopus laevis oocytes expressing skate anion exchanger 1 (AE1).The Journal of membrane biology · 2005Article
- HKT1 mediates sodium uniport in roots. Pitfalls in the expression of HKT1 in yeast.Plant physiology · 2005Article
- Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin.Antimicrobial agents and chemotherapy · 2005Article
- Expression of the skate (Raja erinacea) AE1 osmolyte channel in Xenopus laevis oocytes: monovalent cation permeability.The Journal of membrane biology · 2004Article
- Evidence for the presence of three different anion exchangers in a red cell. Functional expression studies in Xenopus oocytes.The Journal of membrane biology · 2003Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. It was previously shown that expressed in Xenopus oocyte the mouse (mAE1) and the trout (tAE1) anion exchanger behave differently: both elicit anion exchange activity but only tAE1 induces a transport of organic solutes correlated with a chloride channel activity. The present data, obtained by measurement of Xenopus oocyte membrane permeability and conductance, provide evidence that tAE1 also induces a large increase in Na(+) and K(+) permeability inhibited by several AE1 inhibitors. 2. This inhibition does not result from an effect on the driving force for electrodiffusion but represents a direct effect on the cation pathway. 3. As a control, expression of cystic fibrosis transmembrane conductance regulator (CFTR) having, once stimulated by 3-isobutyl-1-methylxanthine (IBMX), the same anion conductance magnitude as tAE1 did not induce any cation movement. 4. Chloride exchange, channel activity and cation transport induced by anion exchanger expression are inhibited by free or covalently bound H2DIDS as well. This covalent inhibition is reversed by the point mutation of Lys-522, the covalent binding site of H2DIDS to the protein. These data reveal that tAE1 itself acts both as an anion exchanger and as a channel of broad selectivity. 5. All results obtained by expression of AE1 isoforms in Xenopus oocytes and those obtained in erythrocytes are consistent with the proposal that, in nucleated erythrocytes, tAE1 functions as the swelling-activated osmolyte anion channel involved in cell volume regulation. In contrast AE1 from mammalian red cells, which do not regulate their volume, lacks swelling-activated osmolyte channel properties. 6. tAE1 illustrates the ability of a specific transport system to be a multifunctional protein exhibiting other transport functions when submitted to regulation.
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