ArticleThe Journal of physiology2001
SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Insights into the mechanisms governing P01 scorpion toxin effect against U87 glioblastoma cells oncogenesis.Frontiers in pharmacology · 2023Article
- PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.The Journal of physiology · 2020Article
- Ethanol Elevates Excitability of Superior Cervical Ganglion Neurons by Inhibiting Kv7 Channels in a Cell Type-Specific and PI(4,5)PInternational journal of molecular sciences · 2019Article
- Article
- Inhibiting bacterial toxins by channel blockage.Pathogens and disease · 2016Review
- Pharmacological enhancement of memory or cognition in normal subjects.Frontiers in systems neuroscience · 2014Review
- The relationship between functional inhibition and binding for K(Ca)2 channel blockers.PloS one · 2013Article
- Platelet-derived growth factor receptor α (PDGFRα)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of humans.Neurogastroenterology and motility · 2012Article
- K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration.Frontiers in pharmacology · 2012Article
- Inhibition of SK and M channel-mediated currents by 5-HT enables parallel processing by bursts and isolated spikes.Journal of neurophysiology · 2011Article
- The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro.Journal of neuroinflammation · 2010Article
- Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.Cellular and molecular life sciences : CMLS · 2008Review
- Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating.Neuron · 2008Article
- K+ channel modulators for the treatment of neurological disorders and autoimmune diseases.Chemical reviews · 2008Review
- Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077).Molecular pharmacology · 2006Article
- Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretion.The Journal of general physiology · 2005Article
- Cloning and characterization of SK2 channel from chicken short hair cells.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Article
- A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Muscarinic receptor modulation of slow afterhyperpolarization and phasic firing in rat supraoptic nucleus neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
1. Our aim was to identify the small-conductance Ca(2+)-activated K(+) channel(s) (SK) underlying the apamin-sensitive afterhyperpolarization (AHP) in rat superior cervical ganglion (SCG) neurones. 2. Degenerate oligonucleotide primers designed to the putative calmodulin-binding domain conserved in all mammalian SK channel sequences were employed to detect SK DNA in a cDNA library from rat SCG. Only a single band, corresponding to a fragment of the rSK3 gene, was amplified. 3. Northern blot analysis employing a PCR-generated rSK3 fragment showed the presence of mRNA coding for SK3 in SCG as well in other rat peripheral tissues including adrenal gland and liver. 4. The same rSK3 fragment enabled the isolation of a full-length rSK3 cDNA from the library. Its sequence was closely similar to, but not identical with, that of the previously reported rSK3 gene. 5. Expression of the rSK3 gene in mammalian cell lines (CHO, HEK cells) caused the appearance of a K(+) conductance with SK channel properties. 6. The application of selective SK blocking agents (including apamin, scyllatoxin and newer non-peptidic compounds) showed these homomeric SK3 channels to have essentially the same pharmacological characteristics as the SCG afterhyperpolarization, but to differ from those of homomeric SK1 and SK2 channels. 7. Immunohistochemistry using a rSK3 antipeptide antibody revealed the presence of SK3 protein in the cell bodies and processes of cultured SCG neurones. 8. Taken together, these results identify SK3 as a major component of the SK channels responsible for the afterhyperpolarization of cultured rat SCG neurones.
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