ArticleThe EMBO journal2001
The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 219 citations in OpenAlex.
- In vivo identification of solar radiation-responsive gene network: role of the p38 stress-dependent kinase.PloS one · 2010Trial
- Targeted Interference with USF2 Binding to the SERPINE1 Proximal Promoter E-Box in Dual Mutant p53Biomedicines · 2026Review
- Gene Expression Profiles of Melanocytes Over-Expressing miR-5110 in Alpaca.Current issues in molecular biology · 2026Article
- Canine parvovirus infection affects host cell nucleolar organization and ribosome biogenesis.Communications biology · 2026Article
- Blue light and ultraviolet radiation: comparative biophysical properties and their roles in skin carcinogenesis and photoaging.Journal of dermato-oncology · 2026Article
- Understanding Mechanisms and Key Factors Influencing Melanogenesis for the Management of Melasma: An Updated Review.Current pharmaceutical biotechnology · 2025Review
- Research progress on peptides that inhibit melanin synthesis.Frontiers in pharmacology · 2025Review
- USF2 and TFEB compete in regulating lysosomal and autophagy genes.Nature communications · 2024Article
- Melanin Inhibitory Effect ofJournal of microbiology and biotechnology · 2024Article
- Genome-Wide Identification and Characterization of MITF Genes in Ruditapes philippinarum and Their Involvement in the Immune Response to Vibrio anguillarum Infection.Biochemical genetics · 2023Article
- Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation.Viruses · 2023Article
- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- Targeting radiation-induced upstream stimulatory factor-1 by histone deacetylase inhibitors to reverse radioresistance in prostate cancer.Cancer reports (Hoboken, N.J.) · 2022Article
- MITF in Normal Melanocytes, Cutaneous and Uveal Melanoma: A Delicate Balance.International journal of molecular sciences · 2022Review
- JNK signaling as a target for anticancer therapy.Pharmacological reports : PR · 2021Review
- Comparative transcriptomics reveals the molecular genetic basis of pigmentation loss inEcology and evolution · 2020Article
- The Association of Residential Altitude on the Molecular Profile and Survival of Melanoma: Results of an Interreg Study.Cancers · 2020Article
- Salidroside can target both P4HB-mediated inflammation and melanogenesis of the skin.Theranostics · 2020Observational
- An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling.F1000Research · 2020Review
- Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells.Journal of assisted reproduction and genetics · 2019Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stress-activated signalling cascade leading to phosphorylation of the p38 family of kinases plays a crucial role during development and in the cellular response to a wide variety of stress-inducing agents. Although alterations in gene expression characteristic of the stress response require the regulation of key transcription factors by the p38 family, few downstream targets for this signalling pathway have been identified. By examining the ability of pigment cells to respond to UV irradiation as part of the UV-induced tanning response, we show that while the microphthalmia-associated transcription factor Mitf regulates basal Tyrosinase expression, it is the ubiquitous basic helix-loop-helix-leucine zipper transcription factor Usf-1 that is required for the UV activation of the Tyrosinase promoter. Consistent with this we demonstrate that Usf-1 is phosphorylated and activated by the stress-responsive p38 kinase. The results suggest that activation of Usf-1 by p38 at a wide variety of viral and cellular promoters will provide a link between stimuli as diverse as UV irradiation, glucose, viral infection and pro-inflammatory cytokines, and the changes in gene expression associated with the stress response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.