ArticleThe EMBO journal2001
Invertebrate connectin spans as much as 3.5 microm in the giant sarcomeres of crayfish claw muscle.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- The Ancestor and Evolution of the Giant Muscle Protein Connectin/Titin.Journal of molecular evolution · 2025Article
- Article
- Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans.The FEBS journal · 2020Article
- Nuclear connectin novex-3 promotes proliferation of hypoxic foetal cardiomyocytes.Scientific reports · 2018Article
- Regulation of structure and function of sarcomeric actin filaments in striated muscle of the nematode Caenorhabditis elegans.Anatomical record (Hoboken, N.J. : 2007) · 2014Review
- Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.Journal of molecular biology · 2010Article
- A constitutive model for muscle properties in a soft-bodied arthropod.Journal of the Royal Society, Interface · 2007Article
- Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle.Molecular biology of the cell · 2006Article
- Molecular and biochemical characterization of kettin in Caenorhabditis elegans.Journal of muscle research and cell motility · 2005Article
- Partial sequence of connectin-like 1200K-protein in obliquely striated muscle of a polychaete (Annelida): evidence for structural diversity from vertebrate and invertebrate connectins.Journal of muscle research and cell motility · 2005Article
- Titin/connectin-related proteins in C. elegans: a review and new findings.Journal of muscle research and cell motility · 2005Review
- The function of elastic proteins in the oscillatory contraction of insect flight muscle.Journal of muscle research and cell motility · 2005Review
- Calcium-dependent molecular spring elements in the giant protein titin.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Malleable conformation of the elastic PEVK segment of titin: non-co-operative interconversion of polyproline II helix, beta-turn and unordered structures.The Biochemical journal · 2003Article
- The entire cDNA sequences of projectin isoforms of crayfish claw closer and flexor muscles and their localization.Journal of muscle research and cell motility · 2003Article
- Varieties of elastic protein in invertebrate muscles.Journal of muscle research and cell motility · 2002Review
- Single-molecule measurement of elasticity of serine-, glutamate- and lysine-rich repeats of invertebrate connectin reveals that its elasticity is caused entropically by random coil structure.Journal of muscle research and cell motility · 2002Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In crayfish claw closer muscle, the giant sarcomeres are 8.3 microm long at rest, four times longer than vertebrate striated muscle sarcomeres, and they are extensible up to 13 microm upon stretch. Invertebrate connectin (I-connectin) is an elastic protein which holds the A band at the center of the sarcomere. The entire sequence of crayfish I-connectin was predicted from cDNA sequences of 53 424 bp (17 352 residues; 1960 kDa). Crayfish I-connectin contains two novel 68- and 71-residue repeats, and also two PEVK domains and one kettin region. Kettin is a small isoform of I-connectin. Immunoblot tests using antibody to the 68-residue repeats revealed the presence of I-connectin also in long sarcomeres of insect leg muscle and barnacle ventral muscle. Immunofluorescence microscopy demonstrated that the two repeats, the long spacer and the two PEVK domains contribute to sarcomere extension. These regions rich in charged amino acids, occupying 63% of the crayfish I-connectin molecule, may allow a span of a 3.5 microm distance as a new class of composite spring.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.