ArticleThe EMBO journal2001
The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 47 citations in OpenAlex.
- Differential impact of genetic deletion of TIGIT or PD-1 on melanoma-specific T-lymphocytes.Oncoimmunology · 2024Article
- Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes.Journal for immunotherapy of cancer · 2020Article
- Next Generation Sequencing of the Pig αβ TCR Repertoire Identifies the Porcine Invariant NKT Cell Receptor.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells.Frontiers in immunology · 2014Article
- Highly diverse TCRα chain repertoire of pre-immune CD8⁺ T cells reveals new insights in gene recombination.The EMBO journal · 2012Article
- MELOE-1 antigen contains multiple HLA class II T cell epitopes recognized by Th1 CD4+ T cells from melanoma patients.PloS one · 2012Article
- Dynamics of the interaction of γδ T cells with their neighbors in vivo.Cellular and molecular life sciences : CMLS · 2011Review
- A long peptide from MELOE-1 contains multiple HLA class II T cell epitopes in addition to the HLA-A*0201 epitope: an attractive candidate for melanoma vaccination.Cancer immunology, immunotherapy : CII · 2011Article
- Numerical modelling of the V-J combinations of the T cell receptor TRA/TRD locus.PLoS computational biology · 2010Article
- Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Quantitative and qualitative changes in V-J alpha rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor alpha chain repertoire.The Journal of experimental medicine · 2002Article
- Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells.OncoimmunologyArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The T-cell receptor (TCR) alpha locus is thought to undergo multiple cycles of secondary rearrangements that maximize the generation of alphabeta T cells. Taking advantage of the nucleotide sequence of the human Valpha and Jalpha segments, we undertook a locus-wide analysis of TCRalpha gene rearrangements in human alphabeta T-cell clones. In most clones, ValphaJalpha rearrangements occurred on both homologous chromosomes and, remarkably, resulted in the use of two neighboring Jalpha segments. No such interallelic coincidence was found for the position of the two rearranged Valpha segments, and there was only a loose correlation between the 5' or 3' chromosomal position of the Valpha and Jalpha segments used in a given rearrangement. These observations question the occurrence of extensive rounds of secondary Valpha-->Jalpha rearrangements and of a coordinated and polarized usage of the Valpha and Jalpha libraries. Fluorescence in situ hybridization analysis of developing T cells in which TCRalpha rearrangements are taking place showed that the interallelic positional coincidence in Jalpha usage cannot be explained by the stable juxtaposition of homologous Jalpha clusters.
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