ArticleThe EMBO journal2001
Glide2, a second glial promoting factor in Drosophila melanogaster.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 69 citations in OpenAlex.
- Evolution of glial cells: a non-bilaterian perspective.Neural development · 2024Review
- Gcm counteracts Toll-induced inflammation and impacts hemocyte number through cholinergic signaling.Frontiers in immunology · 2023Article
- The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Chromatin remodeling during the in vivo glial differentiation in early Drosophila embryos.Scientific reports · 2016Article
- Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila.Genetics · 2016Article
- SoxNeuro orchestrates central nervous system specification and differentiation in Drosophila and is only partially redundant with Dichaete.Genome biology · 2014Article
- Polycomb controls gliogenesis by regulating the transient expression of the Gcm/Glide fate determinant.PLoS genetics · 2012Article
- Systematic screening of Drosophila deficiency mutations for embryonic phenotypes and orphan receptor ligands.PloS one · 2010Article
- Wiser (tsl): a recessive X-linked temperature-sensitive lethal mutation that affects the wings and the eyes in Drosophila melanogaster.Genetica · 2009Article
- Organization and postembryonic development of glial cells in the adult central brain of Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Glial ensheathment of peripheral axons in Drosophila.Journal of neuroscience research · 2008Review
- The GATA factor Serpent cross-regulates lozenge and u-shaped expression during Drosophila blood cell development.Developmental biology · 2007Article
- Glial cell development and function in the Drosophila visual system.Neuron glia biology · 2007Article
- Histone deacetylase 3 binds to and regulates the GCMa transcription factor.Nucleic acids research · 2006Article
- Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.Molecular and cellular biology · 2005Article
- Impacts of a new transcription factor family: mammalian GCM proteins in health and disease.The Journal of cell biology · 2004Review
- Precocious expression of the Glide/Gcm glial-promoting factor in Drosophila induces neurogenesis.Genetics · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fly glial cell deficient/glial cell missing (glide/gcm) gene codes for a transcription factor that induces gliogenesis. Lack of its product eliminates lateral glial cells in the embryonic nervous system. Here we identify a second gene, glide2, that is homologous to glide/gcm in the binding domain and that is also necessary and sufficient to promote glial differentiation. glide2 codes for a transcription factor that displays a weaker and delayed expression compared with glide/gcm. The two genes, which are located 27 kb apart and share cis-regulatory elements, are able to auto- and cross-regulate, indicating that they form a gene complex. Finally, we show that lack of both products eliminates all lateral glial cells, which means that the two genes contain all the fly lateral glial promoting activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.