Evidence map›Paper›PMID 11532206›Full record

ArticleGenome biology2001

Complex genetic diseases: controversy over the Croesus code.

A F Wright, N D Hastie

Open access · bronzeAbstract read
In one paragraph

Article in Genome biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 89 citations in OpenAlex.

  1. Review
  2. Article
  3. Inbreeding among Caribbean Hispanics from the Dominican Republic and its effects on risk of Alzheimer disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2015
    Article
  4. Article
  5. Article
  6. Genetic variation and its role in malignancy.International journal of biomedical science : IJBS · 2011
    Article
  7. Genomic approaches to coronary artery disease.The Indian journal of medical research · 2010
    Review
  8. Review
  9. Article
  10. Review
  11. Current and future directions in genomics of amyotrophic lateral sclerosis.Physical medicine and rehabilitation clinics of North America · 2008
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

A F WrightMRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. alan.wright@hgu.mrc.ed.ac.uk
N D Hastie
Western General Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).

Indexed as

Genetics, MedicalChromosome MappingGene FrequencyGenetic Diseases, InbornGenetic Predisposition to DiseaseGenetic VariationGenome, HumanHaplotypesHuman Genome ProjectHumansMutationPolymorphism, Single Nucleotide

Identifiers

PMID11532206
PMCPMC138948
OpenAlexW1560563502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.