ArticleGenome biology2001
Complex genetic diseases: controversy over the Croesus code.
Article in Genome biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 89 citations in OpenAlex.
- The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan.Cancer biology & medicine · 2023Review
- Inbreeding, Native American ancestry and child mortality: linking human selection and paediatric medicine.Human molecular genetics · 2022Article
- Inbreeding among Caribbean Hispanics from the Dominican Republic and its effects on risk of Alzheimer disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2015Article
- Cost-effectiveness of initial diagnostic strategies for pulmonary nodules presenting to thoracic surgeons.The Annals of thoracic surgery · 2014Article
- What is complex about complex disorders?Genome biology · 2012Article
- Genetic variation and its role in malignancy.International journal of biomedical science : IJBS · 2011Article
- Genomic approaches to coronary artery disease.The Indian journal of medical research · 2010Review
- Genome-wide germline analyses on cancer susceptibility and GeMDBJ database: Gastric cancer as an example.Cancer science · 2010Review
- Interpretation of association signals and identification of causal variants from genome-wide association studies.American journal of human genetics · 2010Article
- Genome-wide association studies and the genetic dissection of complex traits.American journal of hematology · 2009Review
- Current and future directions in genomics of amyotrophic lateral sclerosis.Physical medicine and rehabilitation clinics of North America · 2008Review
- Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.PloS one · 2007Article
- The role of phospholipases A2 in schizophrenia.Molecular psychiatry · 2006Review
- Article
- The prediction of disease risk in genomic medicine.EMBO reports · 2004Article
- Differential expression of S100 gene family in human esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2004Article
- A systematic approach to the assessment of known TNF-alpha polymorphisms in Graves' disease.Genes and immunity · 2004Article
- Designing a multistage, SNP-based, genome screen for common diseases.Journal of human genetics · 2004Article
- Growing evidence for diabetes susceptibility genes from genome scan data.Current diabetes reports · 2003Review
- New methods for finding disease-susceptibility genes: impact and potential.Genome biology · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.