ArticleBMC cell biology2001
MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3.
Article in BMC cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 45 citations in OpenAlex.
- The Mammalian Ocular Lens in Focus: Development, Anatomy, Physiology, Transparency, Biomechanics, and Age-related Challenges.Journal of visualized experiments : JoVE · 2026Review
- Structure of the lens MP20 mediated adhesive junction.Nature communications · 2025Article
- Structure of the lens MP20 mediated adhesive junction.bioRxiv : the preprint server for biology · 2024Article
- Novel and known variants in GJA3 and LIM2 in congenital cataract families from North India.BMC genomics · 2024Article
- Elongated axial length and myopia-related fundus changes associated with the Arg130Cys mutation in theAnnals of translational medicine · 2021Article
- A novel mutation ofInternational journal of ophthalmology · 2020Article
- β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis.Investigative ophthalmology & visual science · 2017Article
- Adhesion/growth-regulatory galectins in the human eye: localization profiles and tissue reactivities as a standard to detect disease-associated alterations.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2012Article
- Absence of mutations in four genes encoding for congenital cataract and expressed in the human brain in Tunisian families with cataract and mental retardation.BMC ophthalmology · 2011Article
- Biological glass: structural determinants of eye lens transparency.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Microphakia and congenital cataract formation in a novel Lim2(C51R) mutant mouse.Molecular vision · 2011Article
- The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors.Molecular neurobiology · 2010Review
- Tissue localization and solubilities of αA-crystallin and its numerous C-terminal truncation products in pre- and postcataractous ICR/f rat lenses.Investigative ophthalmology & visual science · 2010Article
- The prototypical H+/galactose symporter GalP assembles into functional trimers.Journal of molecular biology · 2010Article
- The stratified syncytium of the vertebrate lens.Journal of cell science · 2009Article
- Differentiation-dependent modification and subcellular distribution of aquaporin-0 suggests multiple functional roles in the rat lens.Differentiation; research in biological diversity · 2009Article
- A missense mutation in LIM2 causes autosomal recessive congenital cataract.Molecular vision · 2008Article
- Lengsin expression and function during zebrafish lens formation.Experimental eye research · 2008Article
- Developmental aspects of galectin-3 expression in the lens.Histochemistry and cell biology · 2003Article
- Analysis of binding of mannosides in relation to Langerin (CD207) in Langerhans cells of normal and transformed epithelia.The Histochemical journal · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough MP20 is the second most highly expressed membrane protein in the lens its function remains an enigma. Putative functions for MP20 have recently been inferred from its assignment to the tetraspanin superfamily of integral membrane proteins. Members of this family have been shown to be involved in cellular proliferation, differentiation, migration, and adhesion. In this study, we show that MP20 associates with galectin-3, a known adhesion modulator.
resultsMP20 and galectin-3 co-localized in selected areas of the lens fiber cell plasma membrane. Individually, these proteins purified with apparent molecular masses of 60 kDa and 22 kDa, respectively. A 104 kDa complex was formed in vitro upon mixing the purified proteins. A 102 kDa complex of MP20 and galectin-3 could also be isolated from detergent-solubilized native fiber cell membranes. Binding between MP20 and galectin-3 was disrupted by lactose suggesting the lectin site was involved in the interaction.
conclusionsMP20 adds to a growing list of ligands of galectin-3 and appears to be the first representative of the tetraspanin superfamily identified to possess this specificity.
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