ArticleClinical and experimental immunology2001
Placental cytokine and chemokine production in HIV-1-infected women: trophoblast cells show a different pattern compared to cells from HIV-negative women.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Association between maternal HIV infection and low birth weight and prematurity: a meta-analysis of cohort studies.BMC pregnancy and childbirth · 2015Pooled it
- The Complex Role of CD8+ T Cells in Placental HIV Infection.European journal of immunology · 2025Review
- Effects of Maternal HIV Infection and Alcohol Use in Pregnancy on Birth Outcomes in Uganda.AIDS and behavior · 2024Article
- Assessment of the Integrity and Function of Human Term Placental Explants in Short-Term Culture.Methods and protocols · 2024Article
- Placental Trophoblast Cell Isolation from the Term Placenta.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Effects of HIV Infection on Pregnancy Outcomes Among Women Attending Antenatal Care in Referral Hospitals of the Amhara Regional State, Ethiopia: A Prospective Cohort Study.International journal of women's health · 2022Article
- Human Placental Trophoblasts Infected byFrontiers in immunology · 2021Article
- Association of maternal and infant inflammation with neurodevelopment in HIV-exposed uninfected children in a South African birth cohort.Brain, behavior, and immunity · 2021Article
- Impact of HIV-1 infection on the IGF-1 axis and angiogenic factors in pregnant Cameroonian women receiving antiretroviral therapy.PloS one · 2019Article
- DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births.Epigenetics & chromatin · 2018Article
- Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health.Seminars in immunopathology · 2016Review
- Severity of maternal HIV-1 disease is associated with adverse birth outcomes in Malawian women: a cohort study.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Cytokine dysregulation in early- and late-term placentas from feline immunodeficiency virus (FIV)-infected cats.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Article
- Cell type-specific expression and function of toll-like receptors 2 and 4 in human placenta: implications in fetal infection.Placenta · 2007Article
- Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France.Clinical and experimental immunology · 2007Article
- Relationship of hepatitis B virus infection of placental barrier and hepatitis B virus intra-uterine transmission mechanism.World journal of gastroenterology · 2007Article
- Impact of the placental cytokine-chemokine balance on regulation of cell-cell contact-induced human immunodeficiency virus type 1 translocation across a trophoblastic barrier in vitro.Journal of virology · 2005Article
- A novel CC-chemokine homolog encoded by guinea pig cytomegalovirus.Virus genes · 2002Article
- Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts.The American journal of pathology · 2001Article
- Determinants and outcomes of low birth weight among newborns at a tertiary hospital in Zambia: A retrospective cohort study.Annals of African medicineArticle
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In utero transmission of HIV-1 has been demonstrated and may account for around 10-20% of all materno-fetal HIV-1 transmission. The possible routes for such transmission are transannexial or transplacental. In both cases, the microenvironment (cytokines and chemokines) at the placental interface could be an important regulatory factor in viral transmission. We therefore performed explant cultures of placental villi, and isolated purified trophoblasts, from term placentae obtained from HIV-1-seropositive and HIV-1-seronegative women in order to assess and compare the cytokine and chemokine secretion profiles using ELISA and semiquantitative RT-PCR. No major differences could be seen in the secretions of cytokines and chemokines at the level of whole placental tissue in HIV-1-positive and HIV-1-negative women. However, variations were observed in the expression of inflammatory cytokines and chemokines from trophoblastic cells, depending on the status of HIV-1 infection of the mothers but not the babies, all of which remained uninfected. The significance of these data is discussed.
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