ArticleClinical and experimental immunology2001
The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- From Cytokines to Biomarkers: Mapping the Immunopathology of Inflammatory Bowel Disease.Cells · 2025Review
- Article
- Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis.World journal of gastroenterology · 2018Article
- Inflammatory bowel disease in rats: bacterial and chemical interaction.World journal of gastroenterology · 2008Article
- Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn's disease and age-related changes in Th1/Th2 cytokine profiles.Pediatric research · 2008Article
- Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice.Clinical and experimental immunology · 2006Article
- Acellular Bordetella pertussis vaccine enhances mucosal interleukin-10 production, induces apoptosis of activated Th1 cells and attenuates colitis in Galphai2-deficient mice.Clinical and experimental immunology · 2005Article
- Gut inflammation in the spondyloarthropathies.Current rheumatology reports · 2005Review
- Cytokine production by intestinal intraepithelial lymphocyte subsets in celiac disease.Digestive diseases and sciences · 2005Article
- Structure-modifying capacity of anti-tumour necrosis factor-alpha therapy in ankylosing spondylitis.Drugs · 2004Review
- Protective effect of angelica sinensis polysaccharide on experimental immunological colon injury in rats.World journal of gastroenterology · 2003Article
- Anti-saccharomyces cerevisiae IgA antibodies are raised in ankylosing spondylitis and undifferentiated spondyloarthropathy.Annals of the rheumatic diseases · 2003Article
- Signal transducer and activator of transcription 6 gene G2964A polymorphism and inflammatory bowel disease.Clinical and experimental immunology · 2003Article
- Anti-tumour necrosis factor alpha therapy for ankylosing spondylitis: international experience.Annals of the rheumatic diseases · 2002Review
- Gut inflammation and spondyloarthropathies.Current rheumatology reports · 2002Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T lymphocytes and their cytokines have an important role in the regulation of immune responses in the gut and in the pathogenesis of intestinal inflammation such as in Crohn's disease. The aim of this study was to analyse the Th1/Th2 cytokine profile (IFN-gamma, IL-2, IL-4 and IL-10) in intraepithelial lymphocytes (IEL) and lamina propria lymphocytes (LPL) in Crohn's disease (CD) and ulcerative colitis (UC) in relation to healthy controls (C). Colonic and ileal biopsy specimens were obtained from controls (n = 13) and patients with CD (n = 32). Colonic biopsies were obtained from patients with UC (n = 11). Intracytoplasmic IFN-gamma, IL-2, IL-4 and IL-10 were determined by flow cytometry after PMA-ionomycin stimulation in IEL and LPL. In colonic LPL, a significant proportional decrease of IFN-gamma and IL-2 producing CD3+ cells was observed in patients with CD and UC compared to controls. In ileal LPL, a similar tendency was found although differences were not significant. In IEL no differences in cytokine profiles could be observed. Flow cytometric analysis of intracytoplasmic cytokines at single cell level showed a proportional decrease of IFN-gamma and IL-2 producing T cells in colonic lamina propria in patients with inflammatory bowel disease.
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