ArticleClinical and experimental immunology2001
The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 76 citations in OpenAlex.
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- Influence of IL-β, IL-1RN, and TNF-α variants on the risk of acetylsalicylic acid-induced upper gastrointestinal bleeding: a case-control study.Einstein (Sao Paulo, Brazil) · 2024Article
- Association ofIranian journal of public health · 2018Article
- Early Molecular Events in Murine Gastric Epithelial Cells Mediated by Helicobacter pylori CagA.Helicobacter · 2016Article
- Aspirin and other NSAIDs as chemoprevention agents in melanoma.Cancer prevention research (Philadelphia, Pa.) · 2014Review
- Association of Interleukin-1β and Gene Polymorphisms with Liver Pathogenesis in Hepatitis B Virus Infection among Eastern Indian Population.Journal of clinical and experimental hepatology · 2013Article
- A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection.Clinical and experimental gastroenterology · 2013Article
- Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.Neuro-oncology · 2010Article
- Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians.The American journal of tropical medicine and hygiene · 2009Article
- The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy.Journal of gastroenterology · 2009Article
- TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori-related diseases.Genes and immunity · 2006Article
- Polymorphisms of interleukin-1R receptor antagonist genes in patients with chronic hepatitis B in Iran.World journal of gastroenterology · 2006Article
- CagA-positive Helicobacter pylori infection is not associated with decreased risk of Barrett's esophagus in a population with high H. pylori infection rate.BMC gastroenterology · 2006Article
- Down-regulation of epithelial IL-8 responses in Helicobacter pylori-infected duodenal ulcer patients depends on host factors, rather than bacterial factors.Clinical and experimental immunology · 2005Article
- Article
- Polymorphisms of interleukin-1B and interleukin-1 receptor antagonist genes in patients with chronic hepatitis B.World journal of gastroenterology · 2004Article
- Association of interleukin 1 gene family polymorphisms with duodenal ulcer disease.Clinical and experimental immunology · 2003Article
- Decreased epithelial cytokine responses in the duodenal mucosa of Helicobacter pylori-infected duodenal ulcer patients.Clinical and diagnostic laboratory immunology · 2003Article
- Cytokine gene polymorphism in human disease: on-line databases, supplement 2.Genes and immunity · 2002Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides environmental factors, the genetic background of an individual may contribute to the development and final outcome of peptic ulcer disease. Interleukin-1beta (IL-1beta) and the interleukin-1 receptor antagonist (IL-1ra) are cytokines that play a key role in modulating the inflammatory response in the gastrointestinal mucosa. This study aimed to investigate whether polymorphisms in the IL-1B and IL-RN genes are involved in the susceptibility to and final outcome of peptic ulcer disease. DNA from 179 unrelated Spanish Caucasian patients with peptic ulcer diseases and 99 ethnically matched healthy controls was typed for the TaqI polymorphism at position + 3954 in the IL-1B gene and the variable number of tandem repeats polymorphism in intron 2 of the IL-1RN gene. The determination of Helicobacter pylori status and non-steroidal anti-inflammatory drug (NSAIDs) use was studied in all patients and in controls. H. pylori infection and NSAID use were more frequent in ulcer patients than in controls. There were no significant differences in carriage rate, genotype and allele frequencies of the IL-1RN and the IL-1B(+3954) gene polymorphisms between peptic ulcer patients and controls. However, a strong allelic association between IL-1B and IL-1RN genes was found in duodenal ulcer patients (P < 0.0006). Logistic regression identified H. pylori infection and NSAIDs use as independent risk factors for peptic ulcer diseases whereas the simultaneous carriage of IL-1B(+3954) allele 2 and IL-1RN allele 2 was associated with reduced risk for duodenal ulcer disease (OR: 0.37, 95% CI = 0.14-0.9). Our data suggest that IL-1B and IL-1RN genes in addition to bacterial and environmental factors play a key role in determining the final outcome of peptic ulcer disease.
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