ArticleBritish journal of cancer2001
Frequent genomic imbalances suggest commonly altered tumour genes in human hepatocarcinogenesis.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 64 citations in OpenAlex.
- Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt.Scientific reports · 2026Article
- Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma.Molecular cytogenetics · 2016Article
- MicroRNA expression in hepatitis C virus-related malignancies: A brief review.World journal of gastroenterology · 2015Review
- Genomic losses at 5q13.2 and 8p23.1 in dysplastic hepatocytes are common events in hepatitis B virus-related hepatocellular carcinoma.Oncology letters · 2015Article
- Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.World journal of gastroenterology · 2013Review
- Analysis of genetic damage and gene polymorphism in hepatocellular carcinoma (HCC) patients in a South Indian population.Digestive diseases and sciences · 2013Article
- Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis.Transgenic research · 2012Article
- Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma.Oncogene · 2012Article
- Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma.Acta pharmacologica Sinica · 2010Review
- Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1.Molecular biology of the cell · 2008Article
- Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma.Gut and liver · 2007Article
- Molecular karyotyping of human hepatocellular carcinoma using single-nucleotide polymorphism arrays.Oncogene · 2006Article
- Chronic hepatitis B in hepatocarcinogenesis.Postgraduate medical journal · 2006Review
- Tissue microarray for high-throughput analysis of gene expression profiles in hepatocellular carcinoma.World journal of gastroenterology · 2005Article
- Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors.Cold Spring Harbor symposia on quantitative biology · 2005Article
- Genetic mechanisms of hepatocarcinogenesis.Oncogene · 2002Review
- Identification of frequent cytogenetic aberrations in hepatocellular carcinoma using gene-expression microarray data.Genome biology · 2002Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) is one of the most frequent-occurring malignant tumours worldwide, but molecular changes of tumour DNA, with the exception of viral integrations and p53 mutations, are poorly understood. In order to search for common macro-imbalances of genomic tumour DNA, 21 HCCs and 3 HCC-cell lines were characterized by comparative genomic hybridization (CGH), subsequent database analyses and in selected cases by fluorescence in situ hybridization (FISH). Chromosomal subregions of 1q, 8q, 17q and 20q showed frequent gains of genomic material, while losses were most prevalent in subregions of 4q, 6q, 13q and 16q. Deleted regions encompass tumour suppressor genes, like RB-1 and the cadherin gene cluster, some of them previously identified as potential target genes in HCC development. Several potential growth- or transformation-promoting genes located in chromosomal subregions showed frequent gains of genomic material. The present study provides a basis for further genomic and expression analyses in HCCs and in addition suggests chromosome 4q to carry a so far unidentified tumour suppressor gene relevant for HCC development.
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