ArticleClinical and experimental immunology2001
Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- Immunopathology of Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis.International journal of molecular sciences · 2025Review
- Immune cell crosstalk between ANCA-associated vasculitis and IgG4-related disease: an unresolved pathogenic link.Frontiers in immunology · 2025Review
- The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis.Frontiers in immunology · 2025Article
- Clinical implications of peripheral eosinophil count at diagnosis in patients newly diagnosed with microscopic polyangiitis and granulomatosis with polyangiitis.Arthritis research & therapy · 2023Article
- Granulomatous Inflammation in ANCA-Associated Vasculitis.International journal of molecular sciences · 2021Review
- New Insights Into Novel Therapeutic Targets in ANCA-Associated Vasculitis.Frontiers in immunology · 2021Review
- T-lymphocyte in ANCA-associated vasculitis: what do we know? A pathophysiological and therapeutic approach.Clinical kidney journal · 2019Article
- [Vasculitides and eosinophilic pulmonary diseases].Zeitschrift fur Rheumatologie · 2018Article
- [Vasculitides and eosinophilic pulmonary diseases].Der Internist · 2018Review
- Phenotypic Characterization of Circulating CD4Journal of immunology research · 2018Article
- Dysregulated Responsiveness of Circulating Dendritic Cells to Toll-Like Receptors in ANCA-Associated Vasculitis.Frontiers in immunology · 2017Article
- Eosinophils in vasculitis: characteristics and roles in pathogenesis.Nature reviews. Rheumatology · 2014Review
- Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis.Arthritis research & therapy · 2012Article
- Increased frequency of CCR4+ and CCR6+ memory T-cells including CCR7+CD45RAmed very early memory cells in granulomatosis with polyangiitis (Wegener's).Arthritis research & therapy · 2012Article
- T cells in ANCA-associated vasculitis: what can we learn from lesional versus circulating T cells?Arthritis research & therapy · 2010Review
- Update on pathogenic mechanisms of systemic necrotizing vasculitis.Current rheumatology reports · 2008Review
- Glomerulonephritis, Th1 and Th2: what's new?Clinical and experimental immunology · 2005Review
- Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides.Clinical and experimental immunology · 2005Review
- Autoantigen complementarity: a new theory implicating complementary proteins as initiators of autoimmune disease.Journal of molecular medicine (Berlin, Germany) · 2005Review
- Production of antineutrophil cytoplasm antibodies derived from circulating B cells in patients with systemic vasculitis.Clinical and experimental immunology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wegener's granulomatosis initially affects upper respiratory tract organs including the nasal mucosa in more than 90% of patients. The inflammation is typically granulomatous with associated vasculitis. T lymphocytes are usually a prominent component of the leucocyte infiltrate. Previous studies using peripheral blood T cells have implicated IFN-gamma rich Th1-type responses. This study addressed the cytokine milieu in nasal mucosa from 10 patients with active Wegener's granulomatosis using immunohistochemistry. Increased levels of CD3+ T cells and eosinophils were present compared with normal and disease controls. There was increased expression of IL-4, down-regulation of IL-2 and no detectable IFN-gamma. There was increased expression of the chemokine receptor CCR3 by infiltrating cells, consistent with an IL-4 dominant, Th2-biased response. In contrast, renal biopsy tissue from 10 patients with active Wegener's granulomatosis showed expression of IL-2 and IL-4. The Th2-type environment within nasal mucosa, often the initial site of disease activity in Wegener's, is consistent with a local allergic response in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.