ArticleGenes and immunity2001
Novel SNPs in the CD18 gene validate the association with MPO-ANCA+ vasculitis.
Article in Genes and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Genetics of ANCA-associated Vasculitides.Current rheumatology reports · 2014Review
- Pathophysiological lessons from rare associations of autoimmune diseases.Clinical kidney journal · 2012Article
- Hematologically important mutations: leukocyte adhesion deficiency (first update).Blood cells, molecules & diseases · 2012Review
- Article
- Wegener's granulomatosis: a model of auto-antibodies in mucosal autoimmunity.Clinical immunology (Orlando, Fla.) · 2010Review
- Renal involvement in Wegener's granulomatosis.Clinical reviews in allergy & immunology · 2008Review
- TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis.The Journal of clinical investigation · 2008Article
- Anti-neutrophil cytoplasmic (ANCA) and anti-glomerular basement membrane (GBM) autoantibodies in necrotizing and crescentic glomerulonephritis.Seminars in immunopathology · 2007Review
- Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation.The Journal of clinical investigation · 2006Article
- On the Wegener granulomatosis associated region on chromosome 6p21.3.BMC medical genetics · 2006Article
- Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wegener granulomatosis (WG), microscopic polyangiitis (MP), and Churg-Strauss syndrome (CSS) are characterized by the presence of anti-neutrophil cytoplasmic antibodies (ANCA). Anti-myeloperoxidase (MPO)-ANCA are a typical feature of MP and CSS, while anti-proteinase 3 (PRTN3)-ANCA are highly specific for WG. Several reports indicate that ANCA may directly contribute to pathological processes, ie, through an increase of adhesivity between polymorphonuclear (PMN) and endothelial cells (EC). PMN interact and endothelium interact via the adhesion cascade (AC). CD18 is a key molecule of the AC, as CD18 defects abrogate the adhesion of PMN and cause leukocyte adhesion deficiency, an immunodeficient trait. We have screened the entire coding and regulatory regions of the CD18 gene. Ten single nucleotide polymorphisms (SNP) were identified, four of them showing significant associations with MPO-ANCA(+) vasculitis. One of these SNP's was localized in an alternate transcription initiation site. This polymorphism may influence CD18 gene expression, resulting in dose-dependent increase in adhesion and consecutively facilitated degranulation and respiratory burst. In this manner the pro-adherent genotype may predispose to MPO-ANCA(+) vasculitis.
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