ArticleGenes and immunity2001
The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis.
Article in Genes and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.Nature genetics · 2007Trial
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- Genetic biomarkers for intravenous immunoglobulin response in chronic inflammatory demyelinating polyradiculoneuropathy.European journal of neurology · 2021Article
- T Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes.Nature communications · 2019Article
- Four FCRL3 Gene Polymorphisms (FCRL3_3, _5, _6, _8) Confer Susceptibility to Multiple Sclerosis: Results from a Case-Control Study.Molecular neurobiology · 2016Article
- Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Molecular underpinning of B-cell anergy.Immunological reviews · 2010Review
- Article
- Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7.BMC immunology · 2006Article
- A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.Nature genetics · 2005Article
- Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene.Genes and immunity · 2004Article
- Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice.The Journal of experimental medicine · 2003Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The T cell specific adapter protein (TSAd) encoded by the SH2D2A gene is involved in the control of T cell activation. The gene is located in the 1q21 region, which has been implicated in susceptibility to experimental allergic encephalomyelitis in the mouse. We therefore evaluated whether a polymorphic GA repeat (GA(13)-GA(33)) within the promoter region of the SH2D2A gene shows association to multiple sclerosis (MS). The frequency of the short alleles GA(13-16) was increased among 313 Norwegian MS patients compared to 277 healthy controls (0.332 vs 0.249, OR 1.5, Pc = 0.03). Transmission disequilibrium analysis in 146 Scandinavian families with at least two affected sibs showed increased transmission of GA(16) to MS patients. No linkage or association of MS to four genetic markers flanking the SH2D2A gene was observed. After activation of naive CD4(+) T cells, T cells homozygous for MS associated short alleles displayed lower level of TSAd ex vivo than T cells carrying at least one long allele, which were not associated to MS. Since the SH2D2A protein modulates T cell activation, this may be a mechanism for how short SH2D2A alleles confer susceptibility to develop MS.
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